Epithelial-Mesenchymal Transition gene database (dbEMT) Home
dbEMT
Pediatric cancer database
General information | Literature | Expression | Regulation | Variant | Interaction

Basic Information

Gene ID

7490

Name

WT1

Synonymous

AWT1|EWS-WT1|GUD|NPHS4|WAGR|WIT-2|WT33;Wilms tumor 1;WT1;Wilms tumor 1

Definition

Wilms tumor protein|amino-terminal domain of EWS|last three zinc fingers of the DNA-binding domain of WT1

Position

11p13

Gene Type

protein-coding

Gene Regulation:

Transcription Factors
Post Translational Modification From dbPTM
Methylation Profile From DiseaseMeth database

Transcription Factors   [Top]

Regulation From TransFac database

pawr(h) + WT1(h) <==> pawr(h):WT1(h) (binding)
WT1(h) --> Egr1(m) (DNA binding).
WT1(h) --> IGF2(h) (DNA binding).
WT1(h) --> PDGFA(h) (DNA binding).
WT1(h) --> IGF-1 receptor(r) (DNA binding).
WT1(h) --> FOXD1(h) (DNA binding).
WT1(h) + p53(r) <==> WT1(h):p53(r) (binding)
WT1(h) + p53(h) <==> WT1(h):p53(h) (binding).
p73alpha(mo) + WT1(h) <==> p73alpha(mo):WT1(h) (binding)
WT1(h) --/ IGF-1 receptor(r) (transrepression)
WT1(h) --> WT1(h) (expression).
WT1 I -KTS(h) --> IGF-1 receptor(r) (DNA binding).
p73alpha(mo) + WT1 I -KTS(h) <==> p73alpha(mo):WT1 I -KTS(h) (binding)
p73beta(mo) + WT1 I -KTS(h) <==> p73beta(mo):WT1 I -KTS(h) (binding)
p53(h) + WT1 I -KTS(h) <==> p53(h):WT1 I -KTS(h) (binding)
p63(r) + WT1 I -KTS(h) <==> p63(r):WT1 I -KTS(h) (binding)
WT1 I -KTS(h) --/ IGF-1 receptor(r) (transrepression)
WT1 I -KTS(h) + ER-alpha(m.s.) <==> WT1 I -KTS(h):ER-alpha(m.s.) (binding)
WT1 I -KTS(h) + Slim-3(h) <==> WT1 I -KTS(h):Slim-3(h) (binding)
Slim-3(m.s.) + WT1 I -KTS(h) <==> Slim-3(m.s.):WT1 I -KTS(h) (binding)
WT1 I -KTS(h) --> DAX1(m) (transactivation)
WT1(h) --> WT1 I -KTS(h) (expression).
WT1 -KTS(h) --> IGF-1 receptor(r) (DNA binding).
p73alpha(mo) + WT1 -KTS(h) <==> p73alpha(mo):WT1 -KTS(h) (binding)
WT1 -KTS(h) --/ IGF-1 receptor(r) (transrepression)
WT1(h) --> WT1 -KTS(h) (expression).
WT1 I(h) --> IGF-1 receptor(r) (DNA binding).
p73alpha(mo) + WT1 I(h) <==> p73alpha(mo):WT1 I(h) (binding)
WT1 I(h) --/ IGF-1 receptor(r) (transrepression)
WT1(h) --> WT1 I(h) (expression).
WT1(h) --> WT1-del2(h) (expression).
WT1(h) --> WT1 I-del2(h) (expression).
WT1(h) --> c-myb(h) (DNA binding).
WT1(h) --> TBXA2R(h) (DNA binding).
WT1(h) --> WT1(h) (expression).

Post Translational Modification   [Top]

Location (AA)

PTM type

Literature

Database

Methylation Profile   [Top]

Chromosome

Location

Source

chr11

Promoter: 32413163 - 32415163GoldenGate_Methylation_Cancer_Panel_I

chr11

Promoter: 32413163 - 32415163GoldenGate_Methylation_Cancer_Panel_I

chr11

Promoter: 32413163 - 32415163GoldenGate_Methylation_Cancer_Panel_I

chr11

Promoter: 32413163 - 32415163GoldenGate_Methylation_Cancer_Panel_I

chr11

Promoter: 32413163 - 32415163GSE27584

chr11

Promoter: 32413163 - 32415163GSE27584

chr11

Promoter: 32413163 - 32415163GSE27584

chr11

Promoter: 32413163 - 32415163GSE27584

chr11

Promoter: 32413163 - 32415163Agilent_014791_44K

chr11

Promoter: 32413163 - 32415163E-GEOD-20553

chr11

Promoter: 32413163 - 32415163E-GEOD-20553

chr11

Promoter: 32413163 - 32415163E-GEOD-20553

chr11

Promoter: 32413163 - 32415163E-GEOD-20553

chr11

Promoter: 32413163 - 32415163PMID:16134181

chr11

Promoter: 32413163 - 32415163PMID:16134181

chr11

Promoter: 32413163 - 32415163PMID:16134181

chr11

Promoter: 32413163 - 32415163PMID:16134181

chr11

Promoter: 32413163 - 32415163PMID:17289889

chr11

Promoter: 32413163 - 32415163PMID:17289889

chr11

Promoter: 32413163 - 32415163PMID:17289889

chr11

Promoter: 32413163 - 32415163PMID:17289889

chr11

Promoter: 32413163 - 32415163PMID:15367334

chr11

Promoter: 32413163 - 32415163PMID:15367334

chr11

Promoter: 32413163 - 32415163PMID:15367334

chr11

Promoter: 32413163 - 32415163PMID:15367334

chr11

Promoter: 32413163 - 32415163PMID:16435073

chr11

Promoter: 32413163 - 32415163PMID:16435073

chr11

Promoter: 32413163 - 32415163PMID:16435073

chr11

Promoter: 32413163 - 32415163PMID:16435073


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