Epithelial-Mesenchymal Transition gene database (dbEMT) Home
dbEMT
Pediatric cancer database
General information | Literature | Expression | Regulation | Variant | Interaction

Basic Information

Gene ID

5728

Name

PTEN

Synonymous

10q23del|BZS|DEC|GLM2|MHAM|MMAC1|PTEN1|TEP1;phosphatase and tensin homolog;PTEN;phosphatase and tensin homolog

Definition

MMAC1 phosphatase and tensin homolog deleted on chromosome 10|mutated in multiple advanced cancers 1|phosphatase and tensin-like protein|phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN

Position

10q23.3

Gene Type

protein-coding

Gene Regulation:

Transcription Factors
Post Translational Modification From dbPTM
Methylation Profile From DiseaseMeth database

Transcription Factors   [Top]

Regulation From TransFac database

MVP(h) + PTEN(h) <==> MVP(h):PTEN(h) (binding)
PTEN(h) + 2 ATP --CKII-alpha(h):CKII-alpha2(h):(CKII-beta(h))2--> PTEN(h){pS370}{pS385} + 2 ADP (phosphorylation)
CKII-alpha(h) + PTEN(h) <==> CKII-alpha(h):PTEN(h) (binding)
PTEN(h) + 5 ATP --CKII-alpha(h):CKII-alpha2(h):(CKII-beta(h))2--> PTEN(h){pS370}{pS380}{pT382}{pT383}{pS385} + 5 ADP (phosphorylation)
PTEN(h) + 5 ATP --CKII(mo)--> PTEN(h){pS370}{pS380}{pT382}{pT383}{pS385} + 5 ADP (phosphorylation)
p300(h) + PTEN(h) <==> p300(h):PTEN(h) (binding)
p53(h) + PTEN(h) <==> p53(h):PTEN(h) (binding)
PTEN(h) + 3 ATP --> PTEN(h){pS380}{pT381}{pT382} + 3 ADP (phosphorylation)
PTEN(h) + ubiquitin(h) --> PTEN(h){ub} (ubiquitination)
PTEN(h) --> AKT-1(h){pT308}{pS473} (decrease of phosphorylation)
PTEN(h) --> p21Cip1(h) (increase of abundance)
PTEN(h) --/ Skp2(h) (decrease of abundance)
PTEN(h) --> AKT-1(h){pS473} (decrease of phosphorylation)
HAUSP(h) + PTEN(h) <==> HAUSP(h):PTEN(h) (binding)
PTEN(h) + HAUSP(m.s.) <==> PTEN(h):HAUSP(m.s.) (binding)
PTEN(h) --> PTEN(h) (expression).
estradiol --/ PTEN(h) (decrease of abundance)
p53(h) --> PTEN(h) (increase of abundance)
p53(m.s.) --> PTEN(h) (increase of abundance)
mdm2(m.s.) --/ PTEN(h) (decrease of abundance)
p16INK4a(m.s.) --> PTEN(h) (increase of abundance)
estradiol --> PTEN(h) (increase of abundance)
Fzr(h) --/ PTEN(h) (decrease of abundance)
PTEN(h){ub} --HAUSP(m.s.)--> PTEN(h) + ubiquitin(h) (deubiquitination)
PIP3 --PTEN(h)--> PIP2 + p (dephosphorylation)
PtdIns(3,4)P2 --PTEN(h)--> PtdIns(4)P + p (dephosphorylation)
PtdIns(3)P --PTEN(h)--> PtdIns + p (dephosphorylation)
Ins(1,3,4,5)P4 --PTEN(h)--> IP3 + p (dephosphorylation)
PTEN(h) --> p38(m.s.){p} (decrease of phosphorylation)
PTEN(h) --> PTEN(h) (expression).
PTEN(h) --> PTEN(h) (expression).
hsa-miR-19a --/ PTEN(h) (predicted)
hsa-miR-19b --/ PTEN(h) (predicted)
hsa-miR-214 --/ PTEN(h) (translational repression).

Post Translational Modification   [Top]

Location (AA)

PTM type

Literature

Database

366Phosphothreonine.Swiss-Prot 53.0
370Phosphoserine (by CK2).Swiss-Prot 53.0
385Phosphoserine (by CK2).Swiss-Prot 53.0
401Phosphothreonine.Swiss-Prot 53.0
383Phosphothreonine10866658Phospho.ELM 6.0
380Phosphoserine (CK2 alpha;PK)12077256;10866658;11035045Phospho.ELM 6.0
382Phosphothreonine (CK2 alpha)10866658;11035045Phospho.ELM 6.0
240Phosphotyrosine (Lck)11948419Phospho.ELM 6.0
315Phosphotyrosine (Lck)11948419Phospho.ELM 6.0
229Phosphoserine (ROCK1)15793569Phospho.ELM 6.0
232Phosphothreonine (ROCK1)15793569Phospho.ELM 6.0
362Phosphoserine (GSK-3beta)16107342Phospho.ELM 6.0

Methylation Profile   [Top]

Chromosome

Location

Source

chr10

Promoter: 89611675 - 89613675Agilent_014791

chr10

Promoter: 89611675 - 89613675GoldenGate_Methylation_Cancer_Panel_I

chr10

Promoter: 89611675 - 89613675GSE27584

chr10

Promoter: 89611675 - 89613675Agilent_014791

chr10

Promoter: 89611675 - 89613675PMID:16889486

chr10

Promoter: 89611675 - 89613675PMID:15196854

chr10

Promoter: 89611675 - 89613675PMID:16928264

chr10

Promoter: 89611675 - 89613675PMID:15198948

chr10

Promoter: 89611675 - 89613675PMID:16192589

chr10

Promoter: 89611675 - 89613675PMID:17177027

chr10

Promoter: 89611675 - 89613675PMID:15389252

chr10

Promoter: 89611675 - 89613675PMID:15126336

chr10

Promoter: 89611675 - 89613675PMID:16818626

chr10

Promoter: 89611675 - 89613675PMID:15596045

chr10

Promoter: 89611675 - 89613675PMID:16258501

chr10

Promoter: 89611675 - 89613675PMID:15891996

chr10

Promoter: 89611675 - 89613675PMID:11896207

chr10

Promoter: 89611675 - 89613675PMID:15382065

chr10

Promoter: 89611675 - 89613675PMID:15662588

chr10

Promoter: 89611675 - 89613675PMID:12660822

chr10

Promoter: 89611675 - 89613675PMID:16739377

chr10

Promoter: 89611675 - 89613675PMID:15975525

chr10

Promoter: 89611675 - 89613675PMID:16983315

chr10

Promoter: 89611675 - 89613675PMID:12006535

chr10

Promoter: 89611675 - 89613675PMID:15547698


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