Epithelial-Mesenchymal Transition gene database (dbEMT) Home
dbEMT
Pediatric cancer database
General information | Literature | Expression | Regulation | Variant | Interaction

Basic Information

Gene ID

2321

Name

FLT1

Synonymous

FLT|VEGFR1;fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor);FLT1;fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor)

Definition

FLT-1|VEGFR-1|fms-like tyrosine kinase 1|tyrosine-protein kinase FRT|tyrosine-protein kinase receptor FLT|vascular endothelial growth factor receptor 1|vascular permeability factor receptor

Position

13q12

Gene Type

protein-coding

Gene Regulation:

Transcription Factors
Post Translational Modification From dbPTM
Methylation Profile From DiseaseMeth database

Transcription Factors   [Top]

Regulation From TransFac database

VEGFR-1(h) + Sck(m) <==> VEGFR-1(h):Sck(m) (binding)
VEGFR-1(h) + ATP --> VEGFR-1(h){p} (phosphorylation; automodification)
FLT1(h) --> VEGFR-1(h) (expression).
IFNgamma(h) --> VEGFR-1(h) (increase of secretion).
TGFbeta1(m.s.) --> VEGFR-1(h) (increase of secretion)
TGFbeta2(m.s.) --> VEGFR-1(h) (increase of secretion)
FLT1(h) --> VEGFR-1(h) (expression).

Post Translational Modification   [Top]

Location (AA)

PTM type

Literature

Database

100N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
164N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
196N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
251N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
323N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
402N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
417N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
474N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
547N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
597N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
620N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
625N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
666N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
1053Phosphotyrosine (by autocatalysis) (Bysimilarity).Swiss-Prot 53.0
1169Phosphotyrosine (by autocatalysis) (Bysimilarity).Swiss-Prot 53.0
1213Phosphotyrosine (by autocatalysis).Swiss-Prot 53.0
1242Phosphotyrosine (by autocatalysis).Swiss-Prot 53.0
1327Phosphotyrosine (by autocatalysis).Swiss-Prot 53.0
1333Phosphotyrosine (by autocatalysis).Swiss-Prot 53.0
1242Phosphotyrosine (FLT1)11513746Phospho.ELM 6.0
1327Phosphotyrosine (FLT1)11513746Phospho.ELM 6.0
1169Phosphotyrosine11513746;9299537Phospho.ELM 6.0
794Phosphotyrosine11741094;9398617Phospho.ELM 6.0
1333Phosphotyrosine (FLT1)11513746;9722576;9600074Phospho.ELM 6.0
1213Phosphotyrosine (FLT1)11513746;9722576;9600074Phospho.ELM 6.0

Methylation Profile   [Top]

Chromosome

Location

Source

chr13

Promoter: 27966732 - 27968732Agilent_014791

chr13

Promoter: 27966732 - 27968732GoldenGate_Methylation_Cancer_Panel_I

chr13

Promoter: 27966732 - 27968732GSE27584

chr13

Promoter: 27966732 - 27968732Agilent_014791_44K


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