Epithelial-Mesenchymal Transition gene database (dbEMT) Home
dbEMT
Pediatric cancer database
General information | Literature | Expression | Regulation | Variant | Interaction

Basic Information

Gene ID

7157

Name

TP53

Synonym

LFS1|P53|TRP53;tumor protein p53;TP53;tumor protein p53

Definition

antigen NY-CO-13|cellular tumor antigen p53|p53 tumor suppressor|phosphoprotein p53|transformation-related protein 53|tumor suppressor TP53

Position

17p13.1

Gene Type

protein-coding

Pathways and Diseases

Pathway

estrogen responsive protein efp controls cell cycle and breast tumors growth;PID BioCarta;100182

Pathway

Glucocorticoid receptor regulatory network;PID Curated;200077

Pathway

Neurotrophin signaling pathway;KEGG PATHWAY;hsa04722

Pathway

BARD1 signaling events;PID Curated;200174

Pathway

PLK3 signaling events;PID Curated;200186

Pathway

MAPK signaling pathway;KEGG PATHWAY;hsa04010

Pathway

Endometrial cancer;KEGG PATHWAY;hsa05213

Pathway

regulation of transcriptional activity by pml;PID BioCarta;100067

Pathway

Hypoxic and oxygen homeostasis regulation of HIF-1-alpha;PID Curated;200122

Pathway

Basal cell carcinoma;KEGG PATHWAY;hsa05217

Pathway

cell cycle: g1/s check point;PID BioCarta;100160

Pathway

Huntington's disease;KEGG PATHWAY;hsa05016

Pathway

btg family proteins and cell cycle regulation;PID BioCarta;100224

Pathway

p75(NTR)-mediated signaling;PID Curated;200103

Pathway

Pancreatic cancer;KEGG PATHWAY;hsa05212

Pathway

Wnt signaling pathway;KEGG PATHWAY;hsa04310

Pathway

apoptotic signaling in response to dna damage;PID BioCarta;100204

Pathway

cell cycle: g2/m checkpoint;PID BioCarta;100159

Pathway

Transcriptional activation of cell cycle inhibitor p21;PID Reactome;501023

Pathway

Apoptosis;KEGG PATHWAY;hsa04210

Pathway

Chronic myeloid leukemia;KEGG PATHWAY;hsa05220

Pathway

Small cell lung cancer;KEGG PATHWAY;hsa05222

Pathway

P53 pathway feedback loops 1;PANTHER;P04392

Pathway

Amyotrophic lateral sclerosis (ALS);KEGG PATHWAY;hsa05014

Pathway

tumor suppressor arf inhibits ribosomal biogenesis;PID BioCarta;100237

Pathway

Bladder cancer;KEGG PATHWAY;hsa05219

Pathway

Signaling mediated by p38-alpha and p38-beta;PID Curated;200154

Pathway

Hepatitis C;KEGG PATHWAY;hsa05160

Pathway

atm signaling pathway;PID BioCarta;100235

Pathway

Validated targets of C-MYC transcriptional activation;PID Curated;200045

Pathway

rb tumor suppressor/checkpoint signaling in response to dna damage;PID BioCarta;100046

Pathway

Colorectal cancer;KEGG PATHWAY;hsa05210

Pathway

LKB1 signaling events;PID Curated;200061

Pathway

p53 pathway;PANTHER;P00059

Pathway

Autodegradation of the E3 ubiquitin ligase COP1;PID Reactome;500317

Pathway

Signaling events mediated by HDAC Class III;PID Curated;200020

Pathway

hypoxia and p53 in the cardiovascular system;PID BioCarta;100084

Pathway

p53 signaling pathway;PID BioCarta;100083

Pathway

Wnt signaling pathway;PANTHER;P00057

Pathway

double stranded rna induced gene expression;PID BioCarta;100040

Pathway

p53 pathway by glucose deprivation;PANTHER;P04397

Pathway

Prostate cancer;KEGG PATHWAY;hsa05215

Pathway

AP-1 transcription factor network;PID Curated;200118

Pathway

regulation of cell cycle progression by plk3;PID BioCarta;100068

Pathway

Non-small cell lung cancer;KEGG PATHWAY;hsa05223

Pathway

Aurora A signaling;PID Curated;200166

Pathway

Cell cycle;KEGG PATHWAY;hsa04110

Pathway

Huntington disease;PANTHER;P00029

Pathway

Pathways in cancer;KEGG PATHWAY;hsa05200

Pathway

Thyroid cancer;KEGG PATHWAY;hsa05216

Pathway

p53 pathway;PID Curated;200175

Pathway

Melanoma;KEGG PATHWAY;hsa05218

Pathway

Glioma;KEGG PATHWAY;hsa05214

Pathway

role of brca1 brca2 and atr in cancer susceptibility;PID BioCarta;100234

Pathway

Stabilization of p53;PID Reactome;500316

Pathway

telomeres telomerase cellular aging and immortality;PID BioCarta;100021

Pathway

Cell Cycle Checkpoints;Reactome;REACT:1538

Pathway

Apoptosis signaling pathway;PANTHER;P00006

Pathway

overview of telomerase protein component gene htert transcriptional regulation;PID BioCarta;100019

Pathway

p53 pathway feedback loops 2;PANTHER;P04398

Pathway

p53 signaling pathway;KEGG PATHWAY;hsa04115

Pathway

chaperones modulate interferon signaling pathway;PID BioCarta;100016

Pathway

Direct p53 effectors;PID Curated;200101

Disease

Colorectal cancer;KEGG DISEASE;H00020

Disease

Thyroid cancer;KEGG DISEASE;H00032

Disease

tumour progression;GAD

Disease

Adrenal carcinoma;KEGG DISEASE;H00033

Disease

Colorectal cancer;OMIM

Disease

squamous cell carcinoma;GAD

Disease

tumor progression of BCR/ABL negative chronic myeloproliferative disorders;GAD

Disease

Bladder cancer;KEGG DISEASE;H00022

Disease

Leukemia, Myeloid, Acute;GAD

Disease

Xeroderma pigmentosum;GAD

Disease

Skin cancers;KEGG DISEASE

Disease

aggressive behavior of chondrosarcoma;GAD

Disease

albuminuria among aboriginal Australians;GAD

Disease

brain tumors;GAD

Disease

Osteosarcoma;KEGG DISEASE;H00036

Disease

IMMUNE;GAD

Disease

Breast cancer;OMIM

Disease

Viral infections;KEGG DISEASE

Disease

ring sideroblasts;GAD

Disease

Hairy-cell leukemia;KEGG DISEASE;H00006

Disease

PSYCH;GAD

Disease

Non-small cell lung cancer;KEGG DISEASE;H00014

Disease

metastases;GAD

Disease

colorectal adenocarcinomas;GAD

Disease

Penile cancer;KEGG DISEASE;H00025

Disease

Li-Fraumeni syndrome;OMIM

Disease

decreased chemosensitivity;GAD

Disease

Cancers of the nervous system;KEGG DISEASE

Disease

Small cell lung cancer;KEGG DISEASE;H00013

Disease

Head and neck squamous cell cancer;GAD

Disease

Malignant melanoma;KEGG DISEASE;H00038

Disease

Burkitt lymphoma;KEGG DISEASE;H00008

Disease

smoking;GAD

Disease

Neoplasms;GAD

Disease

cerebral infarct, atherothrombotic;GAD

Disease

skin carcinomas;GAD

Disease

increased aggressiveness;GAD

Disease

Pancreatic cancer;KEGG DISEASE;H00019

Disease

tumor proliferation and other prognostic indicators;GAD

Disease

cervical cancer ovarian cancer;GAD

Disease

Infections caused by retro-transcribing viruses;KEGG DISEASE

Disease

hepatitis C virus infection;GAD

Disease

Multiple myeloma;KEGG DISEASE;H00010

Disease

Vulvar cancer;KEGG DISEASE;H00029

Disease

Cancer of the anal canal;KEGG DISEASE;H00044

Disease

breast cancer by the age of 50 years;GAD

Disease

prostate cancer;GAD

Disease

Li-Fraumeni-like syndrome;OMIM

Disease

Glioblastoma;GAD

Disease

Breast cancer;KEGG DISEASE;H00031

Disease

Lung Neoplasms;GAD

Disease

Adrenal cortical carcinoma;OMIM

Disease

Endometrial cancer;KEGG DISEASE;H00026

Disease

increased lung cancer risk;GAD

Disease

Adult T-cell leukemia;KEGG DISEASE;H00009

Disease

Lymphoma, Large B-Cell, Diffuse;GAD

Disease

Cancers of the urinary system and male genital organs;KEGG DISEASE

Disease

liver cancer;GAD

Disease

CANCER;GAD

Disease

Esophageal cancer;KEGG DISEASE;H00017

Disease

chronic obstructive pulmonary disease/COPD;GAD

Disease

Kaposi's sarcoma;KEGG DISEASE;H00041

Disease

endometrial cancer;GAD

Disease

Osteosarcoma;OMIM

Disease

ulcerative colitis;GAD

Disease

ovarian carcinoma;GAD

Disease

Pancreatic cancer;OMIM

Disease

sensitivity to TZT-1027;GAD

Disease

Basal cell carcinoma;KEGG DISEASE;H00039

Disease

mucosa-associated lymphoid tissue lymphoma;GAD

Disease

metastatic progression and poor survival;GAD

Disease

Choroid plexus papilloma;OMIM

Disease

progression of a prostate carcinoma;GAD

Disease

PHARMACOGENOMIC;GAD

Disease

Choriocarcinoma;KEGG DISEASE;H00028

Disease

METABOLIC;GAD

Disease

Cancers of the digestive system;KEGG DISEASE

Disease

Malignant pleural mesothelioma;KEGG DISEASE;H00015

Disease

colorectal cancer;GAD

Disease

soft tissue sarcoma;GAD

Disease

gastric cancer;GAD

Disease

Hepatocellular carcinoma;KEGG DISEASE;H00048

Disease

Ovarian cancer;KEGG DISEASE;H00027

Disease

Leukemia, Lymphocytic, Chronic, B-Cell;GAD

Disease

pancreatic adenocarcinoma;GAD

Disease

Laryngeal cancer;KEGG DISEASE;H00055

Disease

Squamous cell carcinoma;KEGG DISEASE;H00040

Disease

INFECTION;GAD

Disease

betel-quid chewing;GAD

Disease

Cancers;KEGG DISEASE

Disease

non-small cell lung carcinoma;GAD

Disease

breast cancer;GAD

Disease

ovarian cancer;GAD

Disease

stomach cancer;GAD

Disease

Cholangiocarcinoma;KEGG DISEASE;H00046

Disease

Gastric cancer;KEGG DISEASE;H00018

Disease

Cancers of the lung and pleura;KEGG DISEASE

Disease

Cancers of soft tissues and bone;KEGG DISEASE

Disease

breast carcinoma;GAD

Disease

Nasopharyngeal carcinoma;OMIM

Disease

Chronic myeloid leukemia (CML);KEGG DISEASE;H00004

Disease

colorectal cancers;GAD

Disease

bladder cancer;GAD

Disease

Hepatocellular carcinoma;OMIM

Disease

non-small cell lung cancer;GAD

Disease

lung cancer;GAD

Disease

cervical cancer;GAD

Disease

Cancers of haematopoietic and lymphoid tissues;KEGG DISEASE

Disease

Cancers of endocrine organs;KEGG DISEASE

Disease

DNA Damage;GAD

Disease

oesophageal squamous cell carcinoma;GAD

Disease

psoriatic arthritis;GAD

Disease

malignant myeloid disorders;GAD

Disease

esophageal cancer;GAD

Disease

breast cancer survival;GAD

Disease

malignant cystosarcoma phyllodes and soft tissue sarcoma;GAD

Disease

CARDIOVASCULAR;GAD

Disease

Chronic lymphocytic leukemia (CLL);KEGG DISEASE;H00005

Disease

Oral cancer;KEGG DISEASE;H00016

Disease

Infections caused by dsDNA viruses;KEGG DISEASE

Disease

Cancers of the breast and female genital organs;KEGG DISEASE

Disease

keloid;GAD

Disease

Gallbladder cancer;KEGG DISEASE;H00047

Disease

gastritis, chronic atrophic;GAD

Disease

Glioma;KEGG DISEASE;H00042

Disease

alpha-particle carcinogenesis;GAD

Disease

Head and neck cancers;KEGG DISEASE

Disease

Brain Neoplasms;GAD

External Links

Links to Entrez Gene

7157

Links to all GeneRIF Items

7157

Links to iHOP

7157

Sequence Information

Nucleotide Sequence

>7157 : length: 1182
atggaggagccgcagtcagatcctagcgtcgagccccctctgagtcaggaaacattttca
gacctatggaaactacttcctgaaaacaacgttctgtcccccttgccgtcccaagcaatg
gatgatttgatgctgtccccggacgatattgaacaatggttcactgaagacccaggtcca
gatgaagctcccagaatgccagaggctgctccccccgtggcccctgcaccagcagctcct
acaccggcggcccctgcaccagccccctcctggcccctgtcatcttctgtcccttcccag
aaaacctaccagggcagctacggtttccgtctgggcttcttgcattctgggacagccaag
tctgtgacttgcacgtactcccctgccctcaacaagatgttttgccaactggccaagacc
tgccctgtgcagctgtgggttgattccacacccccgcccggcacccgcgtccgcgccatg
gccatctacaagcagtcacagcacatgacggaggttgtgaggcgctgcccccaccatgag
cgctgctcagatagcgatggtctggcccctcctcagcatcttatccgagtggaaggaaat
ttgcgtgtggagtatttggatgacagaaacacttttcgacatagtgtggtggtgccctat
gagccgcctgaggttggctctgactgtaccaccatccactacaactacatgtgtaacagt
tcctgcatgggcggcatgaaccggaggcccatcctcaccatcatcacactggaagactcc
agtggtaatctactgggacggaacagctttgaggtgcgtgtttgtgcctgtcctgggaga
gaccggcgcacagaggaagagaatctccgcaagaaaggggagcctcaccacgagctgccc
ccagggagcactaagcgagcactgcccaacaacaccagctcctctccccagccaaagaag
aaaccactggatggagaatatttcacccttcagatccgtgggcgtgagcgcttcgagatg
ttccgagagctgaatgaggccttggaactcaaggatgcccaggctgggaaggagccaggg
gggagcagggctcactccagccacctgaagtccaaaaagggtcagtctacctcccgccat
aaaaaactcatgttcaagacagaagggcctgactcagactga

Protein Sequence

>7157 : length: 393
MEEPQSDPSVEPPLSQETFSDLWKLLPENNVLSPLPSQAMDDLMLSPDDIEQWFTEDPGP
DEAPRMPEAAPPVAPAPAAPTPAAPAPAPSWPLSSSVPSQKTYQGSYGFRLGFLHSGTAK
SVTCTYSPALNKMFCQLAKTCPVQLWVDSTPPPGTRVRAMAIYKQSQHMTEVVRRCPHHE
RCSDSDGLAPPQHLIRVEGNLRVEYLDDRNTFRHSVVVPYEPPEVGSDCTTIHYNYMCNS
SCMGGMNRRPILTIITLEDSSGNLLGRNSFEVRVCACPGRDRRTEEENLRKKGEPHHELP
PGSTKRALPNNTSSSPQPKKKPLDGEYFTLQIRGRERFEMFRELNEALELKDAQAGKEPG
GSRAHSSHLKSKKGQSTSRHKKLMFKTEGPDSD



')