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dbEMT
Pediatric cancer database
General information | Literature | Expression | Regulation | Variant | Interaction

Basic Information

Gene ID

6774

Name

STAT3

Synonym

APRF|HIES;signal transducer and activator of transcription 3 (acute-phase response factor);STAT3;signal transducer and activator of transcription 3 (acute-phase response factor)

Definition

DNA-binding protein APRF|acute-phase response factor|signal transducer and activator of transcription 3

Position

17q21.31

Gene Type

protein-coding

Pathways and Diseases

Pathway

Signaling events mediated by TCPTP;PID Curated;200065

Pathway

Signaling events mediated by HDAC Class I;PID Curated;200070

Pathway

role of erbb2 in signal transduction and oncology;PID BioCarta;100147

Pathway

Inflammation mediated by chemokine and cytokine signaling pathway;PANTHER;P00031

Pathway

Signaling in Immune system;Reactome;REACT:6900

Pathway

ErbB1 downstream signaling;PID Curated;200113

Pathway

IL23-mediated signaling events;PID Curated;200131

Pathway

CXCR4-mediated signaling events;PID Curated;200083

Pathway

pdgf signaling pathway;PID BioCarta;100077

Pathway

IL12 signaling mediated by STAT4;PID Curated;200197

Pathway

IL12-mediated signaling events;PID Curated;200034

Pathway

Toxoplasmosis;KEGG PATHWAY;hsa05145

Pathway

Pancreatic cancer;KEGG PATHWAY;hsa05212

Pathway

Signaling by PDGF;Reactome;REACT:16888

Pathway

IL27-mediated signaling events;PID Curated;200023

Pathway

PDGF signaling pathway;PANTHER;P00047

Pathway

egf signaling pathway;PID BioCarta;100181

Pathway

EGF receptor (ErbB1) signaling pathway;PID Curated;200085

Pathway

Neurotrophic factor-mediated Trk receptor signaling;PID Curated;200128

Pathway

PDGFR-beta signaling pathway;PID Curated;200127

Pathway

EGF receptor signaling pathway;PANTHER;P00018

Pathway

IL2-mediated signaling events;PID Curated;200082

Pathway

Notch-mediated HES/HEY network;PID Curated;200196

Pathway

Ras Pathway;PANTHER;P04393

Pathway

Signalling by NGF;Reactome;REACT:11061

Pathway

IFN-gamma pathway;PID Curated;200110

Pathway

Adipocytokine signaling pathway;KEGG PATHWAY;hsa04920

Pathway

ErbB2/ErbB3 signaling events;PID Curated;200119

Pathway

bioactive peptide induced signaling pathway;PID BioCarta;100226

Pathway

Signaling events mediated by PTP1B;PID Curated;200033

Pathway

JAK/STAT signaling pathway;PANTHER;P00038

Pathway

Angiogenesis;PANTHER;P00005

Pathway

erk1/erk2 mapk signaling pathway;PID BioCarta;100170

Pathway

Pathways in cancer;KEGG PATHWAY;hsa05200

Pathway

Hepatitis C;KEGG PATHWAY;hsa05160

Pathway

Jak-STAT signaling pathway;KEGG PATHWAY;hsa04630

Pathway

tpo signaling pathway;PID BioCarta;100012

Pathway

il22 soluble receptor signaling pathway;PID BioCarta;100131

Pathway

Chemokine signaling pathway;KEGG PATHWAY;hsa04062

Pathway

il 6 signaling pathway;PID BioCarta;100126

Pathway

IL6-mediated signaling events;PID Curated;200124

Pathway

RAC1 signaling pathway;PID Curated;200190

Pathway

Interleukin signaling pathway;PANTHER;P00036

Pathway

Signaling events mediated by Stem cell factor receptor (c-Kit);PID Curated;200156

Pathway

stat3 signaling pathway;PID BioCarta;100028

Pathway

GMCSF-mediated signaling events;PID Curated;200015

Pathway

Acute myeloid leukemia;KEGG PATHWAY;hsa05221

Disease

Cancers;KEGG DISEASE

Disease

Other well-defined immunodeficiency syndromes;KEGG DISEASE;H00107

Disease

Multiple sclerosis;NHGRI

Disease

multiple sclerosis;GAD

Disease

IMMUNE;GAD

Disease

Immune system diseases;KEGG DISEASE

Disease

Hyper-IgE recurrent infection syndrome;OMIM

Disease

kidney cancer;GAD

Disease

PHARMACOGENOMIC;GAD

Disease

Oral cancer;KEGG DISEASE;H00016

Disease

Asthma;GAD

Disease

Crohn's disease;GAD

Disease

Head and neck cancers;KEGG DISEASE

Disease

Crohn's disease;NHGRI

Disease

Primary immunodeficiency;KEGG DISEASE

External Links

Links to Entrez Gene

6774

Links to all GeneRIF Items

6774

Links to iHOP

6774

Sequence Information

Nucleotide Sequence

>6774 : length: 2310
atggcccaatggaatcagctacagcagcttgacacacggtacctggagcagctccatcag
ctctacagtgacagcttcccaatggagctgcggcagtttctggccccttggattgagagt
caagattgggcatatgcggccagcaaagaatcacatgccactttggtgtttcataatctc
ctgggagagattgaccagcagtatagccgcttcctgcaagagtcgaatgttctctatcag
cacaatctacgaagaatcaagcagtttcttcagagcaggtatcttgagaagccaatggag
attgcccggattgtggcccggtgcctgtgggaagaatcacgccttctacagactgcagcc
actgcggcccagcaagggggccaggccaaccaccccacagcagccgtggtgacggagaag
cagcagatgctggagcagcaccttcaggatgtccggaagagagtgcaggatctagaacag
aaaatgaaagtggtagagaatctccaggatgactttgatttcaactataaaaccctcaag
agtcaaggagacatgcaagatctgaatggaaacaaccagtcagtgaccaggcagaagatg
cagcagctggaacagatgctcactgcgctggaccagatgcggagaagcatcgtgagtgag
ctggcggggcttttgtcagcgatggagtacgtgcagaaaactctcacggacgaggagctg
gctgactggaagaggcggcaacagattgcctgcattggaggcccgcccaacatctgccta
gatcggctagaaaactggataacgtcattagcagaatctcaacttcagacccgtcaacaa
attaagaaactggaggagttgcagcaaaaagtttcctacaaaggggaccccattgtacag
caccggccgatgctggaggagagaatcgtggagctgtttagaaacttaatgaaaagtgcc
tttgtggtggagcggcagccctgcatgcccatgcatcctgaccggcccctcgtcatcaag
accggcgtccagttcactactaaagtcaggttgctggtcaaattccctgagttgaattat
cagcttaaaattaaagtgtgcattgacaaagactctggggacgttgcagctctcagagga
tcccggaaatttaacattctgggcacaaacacaaaagtgatgaacatggaagaatccaac
aacggcagcctctctgcagaattcaaacacttgaccctgagggagcagagatgtgggaat
gggggccgagccaattgtgatgcttccctgattgtgactgaggagctgcacctgatcacc
tttgagaccgaggtgtatcaccaaggcctcaagattgacctagagacccactccttgcca
gttgtggtgatctccaacatctgtcagatgccaaatgcctgggcgtccatcctgtggtac
aacatgctgaccaacaatcccaagaatgtaaacttttttaccaagcccccaattggaacc
tgggatcaagtggccgaggtcctgagctggcagttctcctccaccaccaagcgaggactg
agcatcgagcagctgactacactggcagagaaactcttgggacctggtgtgaattattca
gggtgtcagatcacatgggctaaattttgcaaagaaaacatggctggcaagggcttctcc
ttctgggtctggctggacaatatcattgaccttgtgaaaaagtacatcctggccctttgg
aacgaagggtacatcatgggctttatcagtaaggagcgggagcgggccatcttgagcact
aagcctccaggcaccttcctgctaagattcagtgaaagcagcaaagaaggaggcgtcact
ttcacttgggtggagaaggacatcagcggtaagacccagatccagtccgtggaaccatac
acaaagcagcagctgaacaacatgtcatttgctgaaatcatcatgggctataagatcatg
gatgctaccaatatcctggtgtctccactggtctatctctatcctgacattcccaaggag
gaggcattcggaaagtattgtcggccagagagccaggagcatcctgaagctgacccaggc
gctgccccatacctgaagaccaagtttatctgtgtgacaccaacgacctgcagcaatacc
attgacctgccgatgtccccccgcactttagattcattgatgcagtttggaaataatggt
gaaggtgctgaaccctcagcaggagggcagtttgagtccctcacctttgacatggagttg
acctcggagtgcgctacctcccccatgtga

Protein Sequence

>6774 : length: 769
MAQWNQLQQLDTRYLEQLHQLYSDSFPMELRQFLAPWIESQDWAYAASKESHATLVFHNL
LGEIDQQYSRFLQESNVLYQHNLRRIKQFLQSRYLEKPMEIARIVARCLWEESRLLQTAA
TAAQQGGQANHPTAAVVTEKQQMLEQHLQDVRKRVQDLEQKMKVVENLQDDFDFNYKTLK
SQGDMQDLNGNNQSVTRQKMQQLEQMLTALDQMRRSIVSELAGLLSAMEYVQKTLTDEEL
ADWKRRQQIACIGGPPNICLDRLENWITSLAESQLQTRQQIKKLEELQQKVSYKGDPIVQ
HRPMLEERIVELFRNLMKSAFVVERQPCMPMHPDRPLVIKTGVQFTTKVRLLVKFPELNY
QLKIKVCIDKDSGDVAALRGSRKFNILGTNTKVMNMEESNNGSLSAEFKHLTLREQRCGN
GGRANCDASLIVTEELHLITFETEVYHQGLKIDLETHSLPVVVISNICQMPNAWASILWY
NMLTNNPKNVNFFTKPPIGTWDQVAEVLSWQFSSTTKRGLSIEQLTTLAEKLLGPGVNYS
GCQITWAKFCKENMAGKGFSFWVWLDNIIDLVKKYILALWNEGYIMGFISKERERAILST
KPPGTFLLRFSESSKEGGVTFTWVEKDISGKTQIQSVEPYTKQQLNNMSFAEIIMGYKIM
DATNILVSPLVYLYPDIPKEEAFGKYCRPESQEHPEADPGAAPYLKTKFICVTPTTCSNT
IDLPMSPRTLDSLMQFGNNGEGAEPSAGGQFESLTFDMELTSECATSPM



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