Epithelial-Mesenchymal Transition gene database (dbEMT) Home
dbEMT
Pediatric cancer database
General information | Literature | Expression | Regulation | Variant | Interaction

Basic Information

Gene ID

673

Name

BRAF

Synonym

B-RAF1|BRAF1|NS7|RAFB1;v-raf murine sarcoma viral oncogene homolog B1;BRAF;v-raf murine sarcoma viral oncogene homolog B1

Definition

94 kDa B-raf protein|B-Raf proto-oncogene serine/threonine-protein kinase (p94)|murine sarcoma viral (v-raf) oncogene homolog B1|p94|proto-oncogene B-Raf|serine/threonine-protein kinase B-raf

Position

7q34

Gene Type

protein-coding

Pathways and Diseases

Pathway

Vascular smooth muscle contraction;KEGG PATHWAY;hsa04270

Pathway

ARMS-mediated activation;PID Reactome;500631

Pathway

Ras signaling in the CD4+ TCR pathway;PID Curated;200088

Pathway

Neurotrophin signaling pathway;KEGG PATHWAY;hsa04722

Pathway

Regulation of actin cytoskeleton;KEGG PATHWAY;hsa04810

Pathway

MAPK signaling pathway;KEGG PATHWAY;hsa04010

Pathway

Endometrial cancer;KEGG PATHWAY;hsa05213

Pathway

Pancreatic cancer;KEGG PATHWAY;hsa05212

Pathway

Focal adhesion;KEGG PATHWAY;hsa04510

Pathway

Chronic myeloid leukemia;KEGG PATHWAY;hsa05220

Pathway

PDGF signaling pathway;PANTHER;P00047

Pathway

mTOR signaling pathway;PID Curated;200080

Pathway

T cell activation;PANTHER;P00053

Pathway

Bladder cancer;KEGG PATHWAY;hsa05219

Pathway

Hepatitis C;KEGG PATHWAY;hsa05160

Pathway

Signalling by NGF;Reactome;REACT:11061

Pathway

Signaling events mediated by focal adhesion kinase;PID Curated;200192

Pathway

Colorectal cancer;KEGG PATHWAY;hsa05210

Pathway

EGF receptor signaling pathway;PANTHER;P00018

Pathway

CDC42 signaling events;PID Curated;200057

Pathway

Insulin signaling pathway;KEGG PATHWAY;hsa04910

Pathway

ErbB signaling pathway;KEGG PATHWAY;hsa04012

Pathway

VEGF signaling pathway;PANTHER;P00056

Pathway

Long-term potentiation;KEGG PATHWAY;hsa04720

Pathway

Progesterone-mediated oocyte maturation;KEGG PATHWAY;hsa04914

Pathway

Downstream signaling in naive CD8+ T cells;PID Curated;200184

Pathway

Trk receptor signaling mediated by the MAPK pathway;PID Curated;200182

Pathway

Frs2-mediated activation;PID Reactome;500630

Pathway

Prostate cancer;KEGG PATHWAY;hsa05215

Pathway

ErbB1 downstream signaling;PID Curated;200113

Pathway

Non-small cell lung cancer;KEGG PATHWAY;hsa05223

Pathway

Angiogenesis;PANTHER;P00005

Pathway

Integrin signalling pathway;PANTHER;P00034

Pathway

mTOR signaling pathway;KEGG PATHWAY;hsa04150

Pathway

Pathways in cancer;KEGG PATHWAY;hsa05200

Pathway

Renal cell carcinoma;KEGG PATHWAY;hsa05211

Pathway

Thyroid cancer;KEGG PATHWAY;hsa05216

Pathway

Melanoma;KEGG PATHWAY;hsa05218

Pathway

Glioma;KEGG PATHWAY;hsa05214

Pathway

Chemokine signaling pathway;KEGG PATHWAY;hsa04062

Pathway

Long-term depression;KEGG PATHWAY;hsa04730

Pathway

Interleukin signaling pathway;PANTHER;P00036

Pathway

Ras Pathway;PANTHER;P04393

Pathway

Natural killer cell mediated cytotoxicity;KEGG PATHWAY;hsa04650

Pathway

Signalling to p38 via RIT and RIN;PID Reactome;500628

Pathway

Acute myeloid leukemia;KEGG PATHWAY;hsa05221

Disease

CANCER;GAD

Disease

Thyroid cancer;KEGG DISEASE;H00032

Disease

Common cold;FunDO

Disease

Cancers;KEGG DISEASE

Disease

Myopathy;FunDO

Disease

Malignant melanoma;KEGG DISEASE;H00038

Disease

Nonsmall cell lung cancer, somatic;OMIM

Disease

Testicular dysfunction;FunDO

Disease

Melanoma, malignant, somatic;OMIM

Disease

Cancers of endocrine organs;KEGG DISEASE

Disease

Metaplastic polyp;FunDO

Disease

colorectal cancer;GAD

Disease

Thyroid gland disease;FunDO

Disease

Cancer;FunDO

Disease

Adenocarcinoma of lung, somatic;OMIM

Disease

Colorectal cancer, somatic;OMIM

Disease

Cardiofaciocutaneous syndrome;OMIM

Disease

Skin cancers;KEGG DISEASE

Disease

Ulcerative colitis;FunDO

Disease

Nephrosis;FunDO

Disease

Angiomyolipoma;FunDO

External Links

Links to Entrez Gene

673

Links to all GeneRIF Items

673

Links to iHOP

673

Sequence Information

Nucleotide Sequence

>673 : length: 2301
atggcggcgctgagcggtggcggtggtggcggcgcggagccgggccaggctctgttcaac
ggggacatggagcccgaggccggcgccggcgccggcgccgcggcctcttcggctgcggac
cctgccattccggaggaggtgtggaatatcaaacaaatgattaagttgacacaggaacat
atagaggccctattggacaaatttggtggggagcataatccaccatcaatatatctggag
gcctatgaagaatacaccagcaagctagatgcactccaacaaagagaacaacagttattg
gaatctctggggaacggaactgatttttctgtttctagctctgcatcaatggataccgtt
acatcttcttcctcttctagcctttcagtgctaccttcatctctttcagtttttcaaaat
cccacagatgtggcacggagcaaccccaagtcaccacaaaaacctatcgttagagtcttc
ctgcccaacaaacagaggacagtggtacctgcaaggtgtggagttacagtccgagacagt
ctaaagaaagcactgatgatgagaggtctaatcccagagtgctgtgctgtttacagaatt
caggatggagagaagaaaccaattggttgggacactgatatttcctggcttactggagaa
gaattgcatgtggaagtgttggagaatgttccacttacaacacacaactttgtacgaaaa
acgtttttcaccttagcattttgtgacttttgtcgaaagctgcttttccagggtttccgc
tgtcaaacatgtggttataaatttcaccagcgttgtagtacagaagttccactgatgtgt
gttaattatgaccaacttgatttgctgtttgtctccaagttctttgaacaccacccaata
ccacaggaagaggcgtccttagcagagactgccctaacatctggatcatccccttccgca
cccgcctcggactctattgggccccaaattctcaccagtccgtctccttcaaaatccatt
ccaattccacagcccttccgaccagcagatgaagatcatcgaaatcaatttgggcaacga
gaccgatcctcatcagctcccaatgtgcatataaacacaatagaacctgtcaatattgat
gacttgattagagaccaaggatttcgtggtgatggaggatcaaccacaggtttgtctgct
accccccctgcctcattacctggctcactaactaacgtgaaagccttacagaaatctcca
ggacctcagcgagaaaggaagtcatcttcatcctcagaagacaggaatcgaatgaaaaca
cttggtagacgggactcgagtgatgattgggagattcctgatgggcagattacagtggga
caaagaattggatctggatcatttggaacagtctacaagggaaagtggcatggtgatgtg
gcagtgaaaatgttgaatgtgacagcacctacacctcagcagttacaagccttcaaaaat
gaagtaggagtactcaggaaaacacgacatgtgaatatcctactcttcatgggctattcc
acaaagccacaactggctattgttacccagtggtgtgagggctccagcttgtatcaccat
ctccatatcattgagaccaaatttgagatgatcaaacttatagatattgcacgacagact
gcacagggcatggattacttacacgccaagtcaatcatccacagagacctcaagagtaat
aatatatttcttcatgaagacctcacagtaaaaataggtgattttggtctagctacagtg
aaatctcgatggagtgggtcccatcagtttgaacagttgtctggatccattttgtggatg
gcaccagaagtcatcagaatgcaagataaaaatccatacagctttcagtcagatgtatat
gcatttggaattgttctgtatgaattgatgactggacagttaccttattcaaacatcaac
aacagggaccagataatttttatggtgggacgaggatacctgtctccagatctcagtaag
gtacggagtaactgtccaaaagccatgaagagattaatggcagagtgcctcaaaaagaaa
agagatgagagaccactctttccccaaattctcgcctctattgagctgctggcccgctca
ttgccaaaaattcaccgcagtgcatcagaaccctccttgaatcgggctggtttccaaaca
gaggattttagtctatatgcttgtgcttctccaaaaacacccatccaggcagggggatat
ggtgcgtttcctgtccactga

Protein Sequence

>673 : length: 766
MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEH
IEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTV
TSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDS
LKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRK
TFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPI
PQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQR
DRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSP
GPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDV
AVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHH
LHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATV
KSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNIN
NRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARS
LPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH



')