Epithelial-Mesenchymal Transition gene database (dbEMT) Home
dbEMT
Pediatric cancer database
General information | Literature | Expression | Regulation | Variant | Interaction

Basic Information

Gene ID

5894

Name

RAF1

Synonym

CRAF|NS5|Raf-1|c-Raf;v-raf-1 murine leukemia viral oncogene homolog 1;RAF1;v-raf-1 murine leukemia viral oncogene homolog 1

Definition

Oncogene RAF1|RAF proto-oncogene serine/threonine-protein kinase|proto-oncogene c-RAF|raf proto-oncogene serine/threonine protein kinase

Position

3p25

Gene Type

protein-coding

Pathways and Diseases

Pathway

il-2 receptor beta chain in t cell activation;PID BioCarta;100129

Pathway

Fc gamma R-mediated phagocytosis;KEGG PATHWAY;hsa04666

Pathway

role of erbb2 in signal transduction and oncology;PID BioCarta;100147

Pathway

Signaling by Insulin receptor;Reactome;REACT:498

Pathway

Axon guidance;Reactome;REACT:18266

Pathway

MAPK signaling pathway;KEGG PATHWAY;hsa04010

Pathway

Endometrial cancer;KEGG PATHWAY;hsa05213

Pathway

pdgf signaling pathway;PID BioCarta;100077

Pathway

sprouty regulation of tyrosine kinase signals;PID BioCarta;100029

Pathway

FGF signaling pathway;PANTHER;P00021

Pathway

Melanogenesis;KEGG PATHWAY;hsa04916

Pathway

Signaling by EGFR;Reactome;REACT:9417

Pathway

PDGF signaling pathway;PANTHER;P00047

Pathway

aspirin blocks signaling pathway involved in platelet activation;PID BioCarta;100030

Pathway

EGF receptor signaling pathway;PANTHER;P00018

Pathway

regulation of splicing through sam68;PID BioCarta;100036

Pathway

inhibition of cellular proliferation by gleevec;PID BioCarta;100154

Pathway

Regulation of retinoblastoma protein;PID Curated;200191

Pathway

Endothelins;PID Curated;200004

Pathway

Progesterone-mediated oocyte maturation;KEGG PATHWAY;hsa04914

Pathway

Fc epsilon RI signaling pathway;KEGG PATHWAY;hsa04664

Pathway

bcr signaling pathway;PID BioCarta;100227

Pathway

erk1/erk2 mapk signaling pathway;PID BioCarta;100170

Pathway

Bladder cancer;KEGG PATHWAY;hsa05219

Pathway

ccr3 signaling in eosinophils;PID BioCarta;100215

Pathway

tpo signaling pathway;PID BioCarta;100012

Pathway

Long-term depression;KEGG PATHWAY;hsa04730

Pathway

role of egf receptor transactivation by gpcrs in cardiac hypertrophy;PID BioCarta;100221

Pathway

Class I PI3K signaling events mediated by Akt;PID Curated;200169

Pathway

multiple antiapoptotic pathways from igf-1r signaling lead to bad phosphorylation;PID BioCarta;100135

Pathway

ErbB2/ErbB3 signaling events;PID Curated;200119

Pathway

signaling pathway from g-protein families;PID BioCarta;100153

Pathway

Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade;PANTHER;P00032

Pathway

BCR signaling pathway;PID Curated;200005

Pathway

Signaling by PDGF;Reactome;REACT:16888

Pathway

mapkinase signaling pathway;PID BioCarta;100113

Pathway

IL2-mediated signaling events;PID Curated;200082

Pathway

CXCR3-mediated signaling events;PID Curated;200150

Pathway

Colorectal cancer;KEGG PATHWAY;hsa05210

Pathway

B cell activation;PANTHER;P00010

Pathway

Downstream signaling in naive CD8+ T cells;PID Curated;200184

Pathway

Trk receptor signaling mediated by the MAPK pathway;PID Curated;200182

Pathway

Prostate cancer;KEGG PATHWAY;hsa05215

Pathway

role of beta-arrestins in the activation and targeting of map kinases;PID BioCarta;100229

Pathway

Angiogenesis;PANTHER;P00005

Pathway

phospholipids as signalling intermediaries;PID BioCarta;100183

Pathway

IGF1 pathway;PID Curated;200084

Pathway

Pathways in cancer;KEGG PATHWAY;hsa05200

Pathway

Melanoma;KEGG PATHWAY;hsa05218

Pathway

Glioma;KEGG PATHWAY;hsa05214

Pathway

ceramide signaling pathway;PID BioCarta;100206

Pathway

influence of ras and rho proteins on g1 to s transition;PID BioCarta;100054

Pathway

melanocyte development and pigmentation pathway;PID BioCarta;100108

Pathway

B cell receptor signaling pathway;KEGG PATHWAY;hsa04662

Pathway

Neurotrophin signaling pathway;KEGG PATHWAY;hsa04722

Pathway

Regulation of actin cytoskeleton;KEGG PATHWAY;hsa04810

Pathway

fmlp induced chemokine gene expression in hmc-1 cells;PID BioCarta;100162

Pathway

trefoil factors initiate mucosal healing;PID BioCarta;100018

Pathway

Ras signaling in the CD4+ TCR pathway;PID Curated;200088

Pathway

Pancreatic cancer;KEGG PATHWAY;hsa05212

Pathway

T cell receptor signaling pathway;KEGG PATHWAY;hsa04660

Pathway

Nongenotropic Androgen signaling;PID Curated;200145

Pathway

Inflammation mediated by chemokine and cytokine signaling pathway;PANTHER;P00031

Pathway

Signalling by NGF;Reactome;REACT:11061

Pathway

CDC42 signaling events;PID Curated;200057

Pathway

Long-term potentiation;KEGG PATHWAY;hsa04720

Pathway

CREB phophorylation through the activation of Ras;PID Reactome;500177

Pathway

keratinocyte differentiation;PID BioCarta;100119

Pathway

Synaptic Transmission;Reactome;REACT:13685

Pathway

angiotensin ii mediated activation of jnk pathway via pyk2 dependent signaling;PID BioCarta;100236

Pathway

Integrin signalling pathway;PANTHER;P00034

Pathway

ras signaling pathway;PID BioCarta;100047

Pathway

Renal cell carcinoma;KEGG PATHWAY;hsa05211

Pathway

nerve growth factor pathway (ngf);PID BioCarta;100096

Pathway

Hemostasis;Reactome;REACT:604

Pathway

role of mal in rho-mediated activation of srf;PID BioCarta;100114

Pathway

Ceramide signaling pathway;PID Curated;200100

Pathway

Internalization of ErbB1;PID Curated;200146

Pathway

phosphorylation of mek1 by cdk5/p35 down regulates the map kinase pathway;PID BioCarta;100210

Pathway

Signaling events mediated by Stem cell factor receptor (c-Kit);PID Curated;200156

Pathway

Natural killer cell mediated cytotoxicity;KEGG PATHWAY;hsa04650

Pathway

GMCSF-mediated signaling events;PID Curated;200015

Pathway

Vascular smooth muscle contraction;KEGG PATHWAY;hsa04270

Pathway

Signaling in Immune system;Reactome;REACT:6900

Pathway

igf-1 signaling pathway;PID BioCarta;100136

Pathway

Fc-epsilon receptor I signaling in mast cells;PID Curated;200003

Pathway

ErbB1 downstream signaling;PID Curated;200113

Pathway

Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met);PID Curated;200032

Pathway

VEGF signaling pathway;KEGG PATHWAY;hsa04370

Pathway

Focal adhesion;KEGG PATHWAY;hsa04510

Pathway

Chronic myeloid leukemia;KEGG PATHWAY;hsa05220

Pathway

Endothelin signaling pathway;PANTHER;P00019

Pathway

T cell activation;PANTHER;P00053

Pathway

role of erk5 in neuronal survival pathway;PID BioCarta;100171

Pathway

Hepatitis C;KEGG PATHWAY;hsa05160

Pathway

Signaling events mediated by focal adhesion kinase;PID Curated;200192

Pathway

roles of beta arrestin dependent recruitment of src kinases in gpcr signaling;PID BioCarta;100230

Pathway

Insulin signaling pathway;KEGG PATHWAY;hsa04910

Pathway

calcium signaling by hbx of hepatitis b virus;PID BioCarta;100150

Pathway

VEGF signaling pathway;PANTHER;P00056

Pathway

ErbB signaling pathway;KEGG PATHWAY;hsa04012

Pathway

Interleukin signaling pathway;PANTHER;P00036

Pathway

links between pyk2 and map kinases;PID BioCarta;100057

Pathway

Non-small cell lung cancer;KEGG PATHWAY;hsa05223

Pathway

t cell receptor signaling pathway;PID BioCarta;100022

Pathway

GnRH signaling pathway;KEGG PATHWAY;hsa04912

Pathway

mTOR signaling pathway;PID Curated;200080

Pathway

fc epsilon receptor i signaling in mast cells;PID BioCarta;100165

Pathway

p38 signaling mediated by MAPKAP kinases;PID Curated;200135

Pathway

Gap junction;KEGG PATHWAY;hsa04540

Pathway

MAP kinase cascade;BioCyc;PWY66-14

Pathway

Chemokine signaling pathway;KEGG PATHWAY;hsa04062

Pathway

cadmium induces dna synthesis and proliferation in macrophages;PID BioCarta;100209

Pathway

RAF activation;PID Reactome;500080

Pathway

Ras Pathway;PANTHER;P04393

Pathway

Acute myeloid leukemia;KEGG PATHWAY;hsa05221

Disease

Herpes;FunDO

Disease

Osteomyelitis;FunDO

Disease

LEOPARD syndrome 2;OMIM

Disease

Vitamin D deficiency;FunDO

Disease

Cancer;FunDO

Disease

Skin disease, Genetic;FunDO

Disease

Noonan syndrome 5;OMIM

Disease

Alzheimer's disease;FunDO

External Links

Links to Entrez Gene

5894

Links to all GeneRIF Items

5894

Links to iHOP

5894

Sequence Information

Nucleotide Sequence

>5894 : length: 1947
atggagcacatacagggagcttggaagacgatcagcaatggttttggattcaaagatgcc
gtgtttgatggctccagctgcatctctcctacaatagttcagcagtttggctatcagcgc
cgggcatcagatgatggcaaactcacagatccttctaagacaagcaacactatccgtgtt
ttcttgccgaacaagcaaagaacagtggtcaatgtgcgaaatggaatgagcttgcatgac
tgccttatgaaagcactcaaggtgaggggcctgcaaccagagtgctgtgcagtgttcaga
cttctccacgaacacaaaggtaaaaaagcacgcttagattggaatactgatgctgcgtct
ttgattggagaagaacttcaagtagatttcctggatcatgttcccctcacaacacacaac
tttgctcggaagacgttcctgaagcttgccttctgtgacatctgtcagaaattcctgctc
aatggatttcgatgtcagacttgtggctacaaatttcatgagcactgtagcaccaaagta
cctactatgtgtgtggactggagtaacatcagacaactcttattgtttccaaattccact
attggtgatagtggagtcccagcactaccttctttgactatgcgtcgtatgcgagagtct
gtttccaggatgcctgttagttctcagcacagatattctacacctcacgccttcaccttt
aacacctccagtccctcatctgaaggttccctctcccagaggcagaggtcgacatccaca
cctaatgtccacatggtcagcaccaccctgcctgtggacagcaggatgattgaggatgca
attcgaagtcacagcgaatcagcctcaccttcagccctgtccagtagccccaacaatctg
agcccaacaggctggtcacagccgaaaacccccgtgccagcacaaagagagcgggcacca
gtatctgggacccaggagaaaaacaaaattaggcctcgtggacagagagattcaagctat
tattgggaaatagaagccagtgaagtgatgctgtccactcggattgggtcaggctctttt
ggaactgtttataagggtaaatggcacggagatgttgcagtaaagatcctaaaggttgtc
gacccaaccccagagcaattccaggccttcaggaatgaggtggctgttctgcgcaaaaca
cggcatgtgaacattctgcttttcatggggtacatgacaaaggacaacctggcaattgtg
acccagtggtgcgagggcagcagcctctacaaacacctgcatgtccaggagaccaagttt
cagatgttccagctaattgacattgcccggcagacggctcagggaatggactatttgcat
gcaaagaacatcatccatagagacatgaaatccaacaatatatttctccatgaaggctta
acagtgaaaattggagattttggtttggcaacagtaaagtcacgctggagtggttctcag
caggttgaacaacctactggctctgtcctctggatggccccagaggtgatccgaatgcag
gataacaacccattcagtttccagtcggatgtctactcctatggcatcgtattgtatgaa
ctgatgacgggggagcttccttattctcacatcaacaaccgagatcagatcatcttcatg
gtgggccgaggatatgcctccccagatcttagtaagctatataagaactgccccaaagca
atgaagaggctggtagctgactgtgtgaagaaagtaaaggaagagaggcctctttttccc
cagatcctgtcttccattgagctgctccaacactctctaccgaagatcaaccggagcgct
tccgagccatccttgcatcgggcagcccacactgaggatatcaatgcttgcacgctgacc
acgtccccgaggctgcctgtcttctag

Protein Sequence

>5894 : length: 648
MEHIQGAWKTISNGFGFKDAVFDGSSCISPTIVQQFGYQRRASDDGKLTDPSKTSNTIRV
FLPNKQRTVVNVRNGMSLHDCLMKALKVRGLQPECCAVFRLLHEHKGKKARLDWNTDAAS
LIGEELQVDFLDHVPLTTHNFARKTFLKLAFCDICQKFLLNGFRCQTCGYKFHEHCSTKV
PTMCVDWSNIRQLLLFPNSTIGDSGVPALPSLTMRRMRESVSRMPVSSQHRYSTPHAFTF
NTSSPSSEGSLSQRQRSTSTPNVHMVSTTLPVDSRMIEDAIRSHSESASPSALSSSPNNL
SPTGWSQPKTPVPAQRERAPVSGTQEKNKIRPRGQRDSSYYWEIEASEVMLSTRIGSGSF
GTVYKGKWHGDVAVKILKVVDPTPEQFQAFRNEVAVLRKTRHVNILLFMGYMTKDNLAIV
TQWCEGSSLYKHLHVQETKFQMFQLIDIARQTAQGMDYLHAKNIIHRDMKSNNIFLHEGL
TVKIGDFGLATVKSRWSGSQQVEQPTGSVLWMAPEVIRMQDNNPFSFQSDVYSYGIVLYE
LMTGELPYSHINNRDQIIFMVGRGYASPDLSKLYKNCPKAMKRLVADCVKKVKEERPLFP
QILSSIELLQHSLPKINRSASEPSLHRAAHTEDINACTLTTSPRLPVF



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