Epithelial-Mesenchymal Transition gene database (dbEMT) Home
dbEMT
Pediatric cancer database
General information | Literature | Expression | Regulation | Variant | Interaction

Basic Information

Gene ID

5728

Name

PTEN

Synonym

10q23del|BZS|DEC|GLM2|MHAM|MMAC1|PTEN1|TEP1;phosphatase and tensin homolog;PTEN;phosphatase and tensin homolog

Definition

MMAC1 phosphatase and tensin homolog deleted on chromosome 10|mutated in multiple advanced cancers 1|phosphatase and tensin-like protein|phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN

Position

10q23.3

Gene Type

protein-coding

Pathways and Diseases

Pathway

Signalling by NGF;Reactome;REACT:11061

Pathway

Tight junction;KEGG PATHWAY;hsa04530

Pathway

superpathway of D-myo-inositol (1,4,5)-trisphosphate metabolism;BioCyc;PWY-6358

Pathway

Phosphatidylinositol signaling system;KEGG PATHWAY;hsa04070

Pathway

Small cell lung cancer;KEGG PATHWAY;hsa05222

Pathway

Direct p53 effectors;PID Curated;200101

Pathway

Endometrial cancer;KEGG PATHWAY;hsa05213

Pathway

RhoA signaling pathway;PID Curated;200007

Pathway

mtor signaling pathway;PID BioCarta;100101

Pathway

PDGFR-beta signaling pathway;PID Curated;200127

Pathway

Class I PI3K signaling events;PID Curated;200098

Pathway

BCR signaling pathway;PID Curated;200005

Pathway

TCR signaling in naive CD4+ T cells;PID Curated;200022

Pathway

pten dependent cell cycle arrest and apoptosis;PID BioCarta;100058

Pathway

Focal adhesion;KEGG PATHWAY;hsa04510

Pathway

skeletal muscle hypertrophy is regulated via akt-mtor pathway;PID BioCarta;100137

Pathway

Inflammation mediated by chemokine and cytokine signaling pathway;PANTHER;P00031

Pathway

PI3 kinase pathway;PANTHER;P00048

Pathway

ctcf: first multivalent nuclear factor;PID BioCarta;100194

Pathway

p53 pathway;PANTHER;P00059

Pathway

Hypoxia response via HIF activation;PANTHER;P00030

Pathway

Inositol phosphate metabolism;KEGG PATHWAY;hsa00562

Pathway

Prostate cancer;KEGG PATHWAY;hsa05215

Pathway

AP-1 transcription factor network;PID Curated;200118

Pathway

Insulin/IGF pathway-protein kinase B signaling cascade;PANTHER;P00033

Pathway

Pathways in cancer;KEGG PATHWAY;hsa05200

Pathway

Melanoma;KEGG PATHWAY;hsa05218

Pathway

Glioma;KEGG PATHWAY;hsa05214

Pathway

D-myo-inositol (1,3,4)-trisphosphate biosynthesis;BioCyc;PWY-6364

Pathway

Signaling in Immune system;Reactome;REACT:6900

Pathway

3-phosphoinositide degradation;BioCyc;PWY-6368

Pathway

p53 pathway feedback loops 2;PANTHER;P04398

Pathway

p53 signaling pathway;KEGG PATHWAY;hsa04115

Pathway

Signaling events mediated by Stem cell factor receptor (c-Kit);PID Curated;200156

Pathway

regulation of eif-4e and p70s6 kinase;PID BioCarta;100178

Disease

Cancers of the lung and pleura;KEGG DISEASE

Disease

PTEN hamartoma tumor syndrome;OMIM

Disease

Meningioma;OMIM

Disease

Skin cancers;KEGG DISEASE

Disease

glioblastoma multiforme;GAD

Disease

Vulvar cancer;KEGG DISEASE;H00029

Disease

VATER association with macrocephaly and ventriculomegaly;OMIM

Disease

anaplastic astrocytoma;GAD

Disease

Macrocephaly/autism syndrome;OMIM

Disease

brain cancer;GAD

Disease

prostate cancer;GAD

Disease

METABOLIC;GAD

Disease

Cancers of the digestive system;KEGG DISEASE

Disease

Breast cancer;KEGG DISEASE;H00031

Disease

diabetes, type 2;GAD

Disease

CHEMDEPENDENCY;GAD

Disease

Glioma susceptibility 2;OMIM

Disease

Hepatocellular carcinoma;KEGG DISEASE;H00048

Disease

Prostate cancer, somatic;OMIM

Disease

CANCER;GAD

Disease

Endometrial cancer;KEGG DISEASE;H00026

Disease

nicotine dependence;GAD

Disease

smoking behavior;GAD

Disease

Cancers of the breast and female genital organs;KEGG DISEASE

Disease

Cancers of the nervous system;KEGG DISEASE

Disease

Cancers;KEGG DISEASE

Disease

Small cell lung cancer;KEGG DISEASE;H00013

Disease

Glioma;KEGG DISEASE;H00042

Disease

Cancers of the urinary system and male genital organs;KEGG DISEASE

Disease

Malignant melanoma;KEGG DISEASE;H00038

Disease

Prostate cancer;KEGG DISEASE;H00024

Disease

Bannayan-Riley-Ruvalcaba syndrome;OMIM

Disease

Cowden disease;OMIM

Disease

ovarian cancer;GAD

Disease

Lhermitte-Duclos syndrome;OMIM

External Links

Links to Entrez Gene

5728

Links to all GeneRIF Items

5728

Links to iHOP

5728

Sequence Information

Nucleotide Sequence

>5728 : length: 1212
atgacagccatcatcaaagagatcgttagcagaaacaaaaggagatatcaagaggatgga
ttcgacttagacttgacctatatttatccaaacattattgctatgggatttcctgcagaa
agacttgaaggcgtatacaggaacaatattgatgatgtagtaaggtttttggattcaaag
cataaaaaccattacaagatatacaatctttgtgctgaaagacattatgacaccgccaaa
tttaattgcagagttgcacaatatccttttgaagaccataacccaccacagctagaactt
atcaaacccttttgtgaagatcttgaccaatggctaagtgaagatgacaatcatgttgca
gcaattcactgtaaagctggaaagggacgaactggtgtaatgatatgtgcatatttatta
catcggggcaaatttttaaaggcacaagaggccctagatttctatggggaagtaaggacc
agagacaaaaagggagtaactattcccagtcagaggcgctatgtgtattattatagctac
ctgttaaagaatcatctggattatagaccagtggcactgttgtttcacaagatgatgttt
gaaactattccaatgttcagtggcggaacttgcaatcctcagtttgtggtctgccagcta
aaggtgaagatatattcctccaattcaggacccacacgacgggaagacaagttcatgtac
tttgagttccctcagccgttacctgtgtgtggtgatatcaaagtagagttcttccacaaa
cagaacaagatgctaaaaaaggacaaaatgtttcacttttgggtaaatacattcttcata
ccaggaccagaggaaacctcagaaaaagtagaaaatggaagtctatgtgatcaagaaatc
gatagcatttgcagtatagagcgtgcagataatgacaaggaatatctagtacttacttta
acaaaaaatgatcttgacaaagcaaataaagacaaagccaaccgatacttttctccaaat
tttaaggtgaagctgtacttcacaaaaacagtagaggagccgtcaaatccagaggctagc
agttcaacttctgtaacaccagatgttagtgacaatgaacctgatcattatagatattct
gacaccactgactctgatccagagaatgaaccttttgatgaagatcagcatacacaaatt
acaaaagtctga

Protein Sequence

>5728 : length: 403
MTAIIKEIVSRNKRRYQEDGFDLDLTYIYPNIIAMGFPAERLEGVYRNNIDDVVRFLDSK
HKNHYKIYNLCAERHYDTAKFNCRVAQYPFEDHNPPQLELIKPFCEDLDQWLSEDDNHVA
AIHCKAGKGRTGVMICAYLLHRGKFLKAQEALDFYGEVRTRDKKGVTIPSQRRYVYYYSY
LLKNHLDYRPVALLFHKMMFETIPMFSGGTCNPQFVVCQLKVKIYSSNSGPTRREDKFMY
FEFPQPLPVCGDIKVEFFHKQNKMLKKDKMFHFWVNTFFIPGPEETSEKVENGSLCDQEI
DSICSIERADNDKEYLVLTLTKNDLDKANKDKANRYFSPNFKVKLYFTKTVEEPSNPEAS
SSTSVTPDVSDNEPDHYRYSDTTDSDPENEPFDEDQHTQITKV



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