Epithelial-Mesenchymal Transition gene database (dbEMT) Home
dbEMT
Pediatric cancer database
General information | Literature | Expression | Regulation | Variant | Interaction

Basic Information

Gene ID

5604

Name

MAP2K1

Synonym

MAPKK1|MEK1|MKK1|PRKMK1;mitogen-activated protein kinase kinase 1;MAP2K1;mitogen-activated protein kinase kinase 1

Definition

ERK activator kinase 1|MAP kinase kinase 1|MAPK/ERK kinase 1|MAPKK 1|MEK 1|dual specificity mitogen-activated protein kinase kinase 1|protein kinase, mitogen-activated, kinase 1 (MAP kinase kinase 1)

Position

15q22.1-q22.33

Gene Type

protein-coding

Pathways and Diseases

Pathway

il-2 receptor beta chain in t cell activation;PID BioCarta;100129

Pathway

Fc gamma R-mediated phagocytosis;KEGG PATHWAY;hsa04666

Pathway

role of erbb2 in signal transduction and oncology;PID BioCarta;100147

Pathway

Signaling by Insulin receptor;Reactome;REACT:498

Pathway

ccr3 signaling in eosinophils;PID BioCarta;100215

Pathway

MAPK signaling pathway;KEGG PATHWAY;hsa04010

Pathway

Endometrial cancer;KEGG PATHWAY;hsa05213

Pathway

pdgf signaling pathway;PID BioCarta;100077

Pathway

sprouty regulation of tyrosine kinase signals;PID BioCarta;100029

Pathway

FGF signaling pathway;PANTHER;P00021

Pathway

Melanogenesis;KEGG PATHWAY;hsa04916

Pathway

Signaling by EGFR;Reactome;REACT:9417

Pathway

EPHB forward signaling;PID Curated;200041

Pathway

ras-independent pathway in nk cell-mediated cytotoxicity;PID BioCarta;100095

Pathway

PDGF signaling pathway;PANTHER;P00047

Pathway

egf signaling pathway;PID BioCarta;100181

Pathway

aspirin blocks signaling pathway involved in platelet activation;PID BioCarta;100030

Pathway

EGF receptor signaling pathway;PANTHER;P00018

Pathway

Axon guidance;Reactome;REACT:18266

Pathway

regulation of splicing through sam68;PID BioCarta;100036

Pathway

IFN-gamma pathway;PID Curated;200110

Pathway

inhibition of cellular proliferation by gleevec;PID BioCarta;100154

Pathway

Hedgehog signaling events mediated by Gli proteins;PID Curated;200147

Pathway

Endothelins;PID Curated;200004

Pathway

Progesterone-mediated oocyte maturation;KEGG PATHWAY;hsa04914

Pathway

Fc epsilon RI signaling pathway;KEGG PATHWAY;hsa04664

Pathway

bcr signaling pathway;PID BioCarta;100227

Pathway

erk1/erk2 mapk signaling pathway;PID BioCarta;100170

Pathway

Bladder cancer;KEGG PATHWAY;hsa05219

Pathway

Toll-like receptor signaling pathway;KEGG PATHWAY;hsa04620

Pathway

tpo signaling pathway;PID BioCarta;100012

Pathway

mcalpain and friends in cell motility;PID BioCarta;100111

Pathway

Long-term depression;KEGG PATHWAY;hsa04730

Pathway

Oocyte meiosis;KEGG PATHWAY;hsa04114

Pathway

role of egf receptor transactivation by gpcrs in cardiac hypertrophy;PID BioCarta;100221

Pathway

Ras signaling in the CD4+ TCR pathway;PID Curated;200088

Pathway

ErbB2/ErbB3 signaling events;PID Curated;200119

Pathway

signaling pathway from g-protein families;PID BioCarta;100153

Pathway

Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade;PANTHER;P00032

Pathway

BCR signaling pathway;PID Curated;200005

Pathway

Signaling by PDGF;Reactome;REACT:16888

Pathway

human cytomegalovirus and map kinase pathways;PID BioCarta;100149

Pathway

mapkinase signaling pathway;PID BioCarta;100113

Pathway

IL2-mediated signaling events;PID Curated;200082

Pathway

CXCR3-mediated signaling events;PID Curated;200150

Pathway

Colorectal cancer;KEGG PATHWAY;hsa05210

Pathway

B cell activation;PANTHER;P00010

Pathway

Downstream signaling in naive CD8+ T cells;PID Curated;200184

Pathway

Trk receptor signaling mediated by the MAPK pathway;PID Curated;200182

Pathway

Prostate cancer;KEGG PATHWAY;hsa05215

Pathway

role of beta-arrestins in the activation and targeting of map kinases;PID BioCarta;100229

Pathway

phospholipids as signalling intermediaries;PID BioCarta;100183

Pathway

Pathways in cancer;KEGG PATHWAY;hsa05200

Pathway

Thyroid cancer;KEGG PATHWAY;hsa05216

Pathway

Melanoma;KEGG PATHWAY;hsa05218

Pathway

Glioma;KEGG PATHWAY;hsa05214

Pathway

ceramide signaling pathway;PID BioCarta;100206

Pathway

influence of ras and rho proteins on g1 to s transition;PID BioCarta;100054

Pathway

melanocyte development and pigmentation pathway;PID BioCarta;100108

Pathway

B cell receptor signaling pathway;KEGG PATHWAY;hsa04662

Pathway

Neurotrophin signaling pathway;KEGG PATHWAY;hsa04722

Pathway

Regulation of actin cytoskeleton;KEGG PATHWAY;hsa04810

Pathway

anthrax toxin mechanism of action;PID BioCarta;100242

Pathway

tgf beta signaling pathway;PID BioCarta;100017

Pathway

fmlp induced chemokine gene expression in hmc-1 cells;PID BioCarta;100162

Pathway

trefoil factors initiate mucosal healing;PID BioCarta;100018

Pathway

Pancreatic cancer;KEGG PATHWAY;hsa05212

Pathway

T cell receptor signaling pathway;KEGG PATHWAY;hsa04660

Pathway

Nongenotropic Androgen signaling;PID Curated;200145

Pathway

Ras Pathway;PANTHER;P04393

Pathway

Signalling by NGF;Reactome;REACT:11061

Pathway

Long-term potentiation;KEGG PATHWAY;hsa04720

Pathway

keratinocyte differentiation;PID BioCarta;100119

Pathway

angiotensin ii mediated activation of jnk pathway via pyk2 dependent signaling;PID BioCarta;100236

Pathway

Integrin signalling pathway;PANTHER;P00034

Pathway

Class IB PI3K non-lipid kinase events;PID Curated;200081

Pathway

Renal cell carcinoma;KEGG PATHWAY;hsa05211

Pathway

nerve growth factor pathway (ngf);PID BioCarta;100096

Pathway

Prion diseases;KEGG PATHWAY;hsa05020

Pathway

role of mal in rho-mediated activation of srf;PID BioCarta;100114

Pathway

erk and pi-3 kinase are necessary for collagen binding in corneal epithelia;PID BioCarta;100184

Pathway

Ceramide signaling pathway;PID Curated;200100

Pathway

phosphorylation of mek1 by cdk5/p35 down regulates the map kinase pathway;PID BioCarta;100210

Pathway

Signaling events mediated by Stem cell factor receptor (c-Kit);PID Curated;200156

Pathway

Natural killer cell mediated cytotoxicity;KEGG PATHWAY;hsa04650

Pathway

GMCSF-mediated signaling events;PID Curated;200015

Pathway

Vascular smooth muscle contraction;KEGG PATHWAY;hsa04270

Pathway

Signaling in Immune system;Reactome;REACT:6900

Pathway

igf-1 signaling pathway;PID BioCarta;100136

Pathway

Fc-epsilon receptor I signaling in mast cells;PID Curated;200003

Pathway

ErbB1 downstream signaling;PID Curated;200113

Pathway

RAF phosphorylates MEK;PID Reactome;500083

Pathway

Toll receptor signaling pathway;PANTHER;P00054

Pathway

Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met);PID Curated;200032

Pathway

FOXM1 transcription factor network;PID Curated;200120

Pathway

VEGF signaling pathway;KEGG PATHWAY;hsa04370

Pathway

Focal adhesion;KEGG PATHWAY;hsa04510

Pathway

Chronic myeloid leukemia;KEGG PATHWAY;hsa05220

Pathway

Endothelin signaling pathway;PANTHER;P00019

Pathway

T cell activation;PANTHER;P00053

Pathway

Neurotrophic factor-mediated Trk receptor signaling;PID Curated;200128

Pathway

role of erk5 in neuronal survival pathway;PID BioCarta;100171

Pathway

Signaling events mediated by focal adhesion kinase;PID Curated;200192

Pathway

Dorso-ventral axis formation;KEGG PATHWAY;hsa04320

Pathway

map kinase inactivation of smrt corepressor;PID BioCarta;100032

Pathway

roles of beta arrestin dependent recruitment of src kinases in gpcr signaling;PID BioCarta;100230

Pathway

Insulin signaling pathway;KEGG PATHWAY;hsa04910

Pathway

calcium signaling by hbx of hepatitis b virus;PID BioCarta;100150

Pathway

ErbB signaling pathway;KEGG PATHWAY;hsa04012

Pathway

links between pyk2 and map kinases;PID BioCarta;100057

Pathway

Cellular roles of Anthrax toxin;PID Curated;200179

Pathway

Non-small cell lung cancer;KEGG PATHWAY;hsa05223

Pathway

Signal transduction by L1;PID Reactome;500100

Pathway

t cell receptor signaling pathway;PID BioCarta;100022

Pathway

GnRH signaling pathway;KEGG PATHWAY;hsa04912

Pathway

mTOR signaling pathway;PID Curated;200080

Pathway

fc epsilon receptor i signaling in mast cells;PID BioCarta;100165

Pathway

Gap junction;KEGG PATHWAY;hsa04540

Pathway

MAP kinase cascade;BioCyc;PWY66-14

Pathway

Chemokine signaling pathway;KEGG PATHWAY;hsa04062

Pathway

ERK1 activation;PID Reactome;500085

Pathway

cadmium induces dna synthesis and proliferation in macrophages;PID BioCarta;100209

Pathway

Netrin-mediated signaling;PID Curated;200074

Pathway

Acute myeloid leukemia;KEGG PATHWAY;hsa05221

Disease

Cardiofaciocutaneous syndrome;OMIM

External Links

Links to Entrez Gene

5604

Links to all GeneRIF Items

5604

Links to iHOP

5604

Sequence Information

Nucleotide Sequence

>5604 : length: 1182
atgcccaagaagaagccgacgcccatccagctgaacccggcccccgacggctctgcagtt
aacgggaccagctctgcggagaccaacttggaggccttgcagaagaagctggaggagcta
gagcttgatgagcagcagcgaaagcgccttgaggcctttcttacccagaagcagaaggtg
ggagaactgaaggatgacgactttgagaagatcagtgagctgggggctggcaatggcggt
gtggtgttcaaggtctcccacaagccttctggcctggtcatggccagaaagctaattcat
ctggagatcaaacccgcaatccggaaccagatcataagggagctgcaggttctgcatgag
tgcaactctccgtacatcgtgggcttctatggtgcgttctacagcgatggcgagatcagt
atctgcatggagcacatggatggaggttctctggatcaagtcctgaagaaagctggaaga
attcctgaacaaattttaggaaaagttagcattgctgtaataaaaggcctgacatatctg
agggagaagcacaagatcatgcacagagatgtcaagccctccaacatcctagtcaactcc
cgtggggagatcaagctctgtgactttggggtcagcgggcagctcatcgactccatggcc
aactccttcgtgggcacaaggtcctacatgtcgccagaaagactccaggggactcattac
tctgtgcagtcagacatctggagcatgggactgtctctggtagagatggcggttgggagg
tatcccatccctcctccagatgccaaggagctggagctgatgtttgggtgccaggtggaa
ggagatgcggctgagaccccacccaggccaaggacccccgggaggccccttagctcatac
ggaatggacagccgacctcccatggcaatttttgagttgttggattacatagtcaacgag
cctcctccaaaactgcccagtggagtgttcagtctggaatttcaagattttgtgaataaa
tgcttaataaaaaaccccgcagagagagcagatttgaagcaactcatggttcatgctttt
atcaagagatctgatgctgaggaagtggattttgcaggttggctctgctccaccatcggc
cttaaccagcccagcacaccaacccatgctgctggcgtctaa

Protein Sequence

>5604 : length: 393
MPKKKPTPIQLNPAPDGSAVNGTSSAETNLEALQKKLEELELDEQQRKRLEAFLTQKQKV
GELKDDDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQIIRELQVLHE
CNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLTYL
REKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSFVGTRSYMSPERLQGTHY
SVQSDIWSMGLSLVEMAVGRYPIPPPDAKELELMFGCQVEGDAAETPPRPRTPGRPLSSY
GMDSRPPMAIFELLDYIVNEPPPKLPSGVFSLEFQDFVNKCLIKNPAERADLKQLMVHAF
IKRSDAEEVDFAGWLCSTIGLNQPSTPTHAAGV



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