Epithelial-Mesenchymal Transition gene database (dbEMT) Home
dbEMT
Pediatric cancer database
General information | Literature | Expression | Regulation | Variant | Interaction

Basic Information

Gene ID

3845

Name

KRAS

Synonym

C-K-RAS|K-RAS2A|K-RAS2B|K-RAS4A|K-RAS4B|KI-RAS|KRAS1|KRAS2|NS|NS3|RASK2;v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog;KRAS;v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog

Definition

GTPase KRas|K-Ras 2|K-ras p21 protein|Kirsten rat sarcoma-2 viral (v-Ki-ras2) oncogene homolog|PR310 c-K-ras oncogene|c-Ki-ras|c-Kirsten-ras protein|cellular c-Ki-ras2 proto-oncogene|oncogene KRAS2|transforming protein p21|v-Ki-ras2 Kirsten rat sarcoma 2

Position

12p12.1

Gene Type

protein-coding

Pathways and Diseases

Pathway

B cell receptor signaling pathway;KEGG PATHWAY;hsa04662

Pathway

Neurotrophin signaling pathway;KEGG PATHWAY;hsa04722

Pathway

Signaling by Insulin receptor;Reactome;REACT:498

Pathway

Axon guidance;Reactome;REACT:18266

Pathway

Regulation of actin cytoskeleton;KEGG PATHWAY;hsa04810

Pathway

Inflammation mediated by chemokine and cytokine signaling pathway;PANTHER;P00031

Pathway

MAPK signaling pathway;KEGG PATHWAY;hsa04010

Pathway

Endometrial cancer;KEGG PATHWAY;hsa05213

Pathway

TGF-beta signaling pathway;PANTHER;P00052

Pathway

telomeres telomerase cellular aging and immortality;PID BioCarta;100021

Pathway

FGF signaling pathway;PANTHER;P00021

Pathway

Colorectal cancer;KEGG PATHWAY;hsa05210

Pathway

Pancreatic cancer;KEGG PATHWAY;hsa05212

Pathway

VEGF signaling pathway;KEGG PATHWAY;hsa04370

Pathway

Melanogenesis;KEGG PATHWAY;hsa04916

Pathway

Signaling by EGFR;Reactome;REACT:9417

Pathway

T cell activation;PANTHER;P00053

Pathway

Chronic myeloid leukemia;KEGG PATHWAY;hsa05220

Pathway

Pathways in cancer;KEGG PATHWAY;hsa05200

Pathway

T cell receptor signaling pathway;KEGG PATHWAY;hsa04660

Pathway

PDGF signaling pathway;PANTHER;P00047

Pathway

Axon guidance;KEGG PATHWAY;hsa04360

Pathway

Bladder cancer;KEGG PATHWAY;hsa05219

Pathway

Hepatitis C;KEGG PATHWAY;hsa05160

Pathway

PI3 kinase pathway;PANTHER;P00048

Pathway

Aldosterone-regulated sodium reabsorption;KEGG PATHWAY;hsa04960

Pathway

EGF receptor signaling pathway;PANTHER;P00018

Pathway

Insulin signaling pathway;KEGG PATHWAY;hsa04910

Pathway

ErbB signaling pathway;KEGG PATHWAY;hsa04012

Pathway

Signaling by PDGF;Reactome;REACT:16888

Pathway

VEGF signaling pathway;PANTHER;P00056

Pathway

Long-term potentiation;KEGG PATHWAY;hsa04720

Pathway

Progesterone-mediated oocyte maturation;KEGG PATHWAY;hsa04914

Pathway

Fc epsilon RI signaling pathway;KEGG PATHWAY;hsa04664

Pathway

Prostate cancer;KEGG PATHWAY;hsa05215

Pathway

Non-small cell lung cancer;KEGG PATHWAY;hsa05223

Pathway

Angiogenesis;PANTHER;P00005

Pathway

Integrin signalling pathway;PANTHER;P00034

Pathway

GnRH signaling pathway;KEGG PATHWAY;hsa04912

Pathway

Renal cell carcinoma;KEGG PATHWAY;hsa05211

Pathway

Thyroid cancer;KEGG PATHWAY;hsa05216

Pathway

Melanoma;KEGG PATHWAY;hsa05218

Pathway

Glioma;KEGG PATHWAY;hsa05214

Pathway

Signalling by NGF;Reactome;REACT:11061

Pathway

Gap junction;KEGG PATHWAY;hsa04540

Pathway

Hemostasis;Reactome;REACT:604

Pathway

Chemokine signaling pathway;KEGG PATHWAY;hsa04062

Pathway

Tight junction;KEGG PATHWAY;hsa04530

Pathway

Long-term depression;KEGG PATHWAY;hsa04730

Pathway

Dorso-ventral axis formation;KEGG PATHWAY;hsa04320

Pathway

p53 pathway feedback loops 2;PANTHER;P04398

Pathway

Ras Pathway;PANTHER;P04393

Pathway

Natural killer cell mediated cytotoxicity;KEGG PATHWAY;hsa04650

Pathway

Acute myeloid leukemia;KEGG PATHWAY;hsa05221

Disease

Colorectal cancer;KEGG DISEASE;H00020

Disease

Thyroid cancer;KEGG DISEASE;H00032

Disease

Cholangiocarcinoma;KEGG DISEASE;H00046

Disease

leukemia, myeloid;GAD

Disease

vinyl chloride exposure;GAD

Disease

Gastric cancer;KEGG DISEASE;H00018

Disease

Pancreatic cancer;KEGG DISEASE;H00019

Disease

Pancreatic carcinoma, somatic;OMIM

Disease

lung adenocarcinoma;GAD

Disease

Cancer;FunDO

Disease

Cancers of the breast and female genital organs;KEGG DISEASE

Disease

Bladder cancer;OMIM

Disease

Kaposi's sarcoma;KEGG DISEASE;H00041

Disease

colon cancer;GAD

Disease

Mouth Neoplasms;GAD

Disease

Multiple myeloma;KEGG DISEASE;H00010

Disease

Skin cancers;KEGG DISEASE

Disease

Pancreatitis;FunDO

Disease

lung cancer;GAD

Disease

Cancers of haematopoietic and lymphoid tissues;KEGG DISEASE

Disease

PHARMACOGENOMIC;GAD

Disease

Cancers of endocrine organs;KEGG DISEASE

Disease

Cancers of the lung and pleura;KEGG DISEASE

Disease

Polycystic ovary syndrome;FunDO

Disease

Carcinoma, Squamous Cell;GAD

Disease

Cancers of the digestive system;KEGG DISEASE

Disease

Breast cancer, somatic;OMIM

Disease

Viral infections;KEGG DISEASE

Disease

breast cancer colorectal cancer stomach cancer;GAD

Disease

colorectal cancer;GAD

Disease

smoking;GAD

Disease

esophageal cancer;GAD

Disease

Non-small cell lung cancer;KEGG DISEASE;H00014

Disease

Penile disease;FunDO

Disease

Stomach cancer;OMIM

Disease

Hepatocellular carcinoma;KEGG DISEASE;H00048

Disease

Ovarian cancer;KEGG DISEASE;H00027

Disease

Testicular dysfunction;FunDO

Disease

Endometrial cancer;KEGG DISEASE;H00026

Disease

mucinous ovarian tumor;GAD

Disease

Infections caused by dsDNA viruses;KEGG DISEASE

Disease

Cardiofaciocutaneous syndrome;OMIM

Disease

Squamous cell carcinoma;KEGG DISEASE;H00040

Disease

Endometriosis;FunDO

Disease

Gallbladder cancer;KEGG DISEASE;H00047

Disease

Cancers;KEGG DISEASE

Disease

decreased apoptosis.;GAD

Disease

Cervical cancer;KEGG DISEASE;H00030

Disease

Acute myeloid leukemia (AML);KEGG DISEASE;H00003

Disease

Leukemia, acute myelogenous;OMIM

Disease

pancreatic carcinoma;GAD

Disease

CANCER;GAD

Disease

Lung cancer;OMIM

Disease

Oral cancer;KEGG DISEASE;H00016

Disease

Head and neck cancers;KEGG DISEASE

Disease

Noonan syndrome 3;OMIM

External Links

Links to Entrez Gene

3845

Links to all GeneRIF Items

3845

Links to iHOP

3845

Sequence Information

Nucleotide Sequence

>3845 : length: 567
atgactgaatataaacttgtggtagttggagctggtggcgtaggcaagagtgccttgacg
atacagctaattcagaatcattttgtggacgaatatgatccaacaatagaggattcctac
aggaagcaagtagtaattgatggagaaacctgtctcttggatattctcgacacagcaggt
caagaggagtacagtgcaatgagggaccagtacatgaggactggggagggctttctttgt
gtatttgccataaataatactaaatcatttgaagatattcaccattatagagaacaaatt
aaaagagttaaggactctgaagatgtacctatggtcctagtaggaaataaatgtgatttg
ccttctagaacagtagacacaaaacaggctcaggacttagcaagaagttatggaattcct
tttattgaaacatcagcaaagacaagacagggtgttgatgatgccttctatacattagtt
cgagaaattcgaaaacataaagaaaagatgagcaaagatggtaaaaagaagaaaaagaag
tcaaagacaaagtgtgtaattatgtaa

Protein Sequence

>3845 : length: 188
MTEYKLVVVGAGGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAG
QEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDL
PSRTVDTKQAQDLARSYGIPFIETSAKTRQGVDDAFYTLVREIRKHKEKMSKDGKKKKKK
SKTKCVIM



')