Epithelial-Mesenchymal Transition gene database (dbEMT) Home
dbEMT
Pediatric cancer database
General information | Literature | Expression | Regulation | Variant | Interaction

Basic Information

Gene ID

3265

Name

HRAS

Synonym

C-BAS/HAS|C-H-RAS|C-HA-RAS1|CTLO|H-RASIDX|HAMSV|HRAS1|K-RAS|N-RAS|RASH1;v-Ha-ras Harvey rat sarcoma viral oncogene homolog;HRAS;v-Ha-ras Harvey rat sarcoma viral oncogene homolog

Definition

GTP- and GDP-binding peptide B|GTPase HRas|H-Ras-1|Ha-Ras1 proto-oncoprotein|Ras family small GTP binding protein H-Ras|c-has/bas p21 protein|c-ras-Ki-2 activated oncogene|ha-Ras|p19 H-RasIDX protein|p21ras|transformation gene: oncogene HAMSV|transforming

Position

11p15.5

Gene Type

protein-coding

Pathways and Diseases

Pathway

il-2 receptor beta chain in t cell activation;PID BioCarta;100129

Pathway

role of erbb2 in signal transduction and oncology;PID BioCarta;100147

Pathway

Signaling by Insulin receptor;Reactome;REACT:498

Pathway

Axon guidance;Reactome;REACT:18266

Pathway

MAPK signaling pathway;KEGG PATHWAY;hsa04010

Pathway

Endometrial cancer;KEGG PATHWAY;hsa05213

Pathway

insulin signaling pathway;PID BioCarta;100124

Pathway

TGF-beta signaling pathway;PANTHER;P00052

Pathway

pdgf signaling pathway;PID BioCarta;100077

Pathway

PDGFR-beta signaling pathway;PID Curated;200127

Pathway

sprouty regulation of tyrosine kinase signals;PID BioCarta;100029

Pathway

FGF signaling pathway;PANTHER;P00021

Pathway

Melanogenesis;KEGG PATHWAY;hsa04916

Pathway

Signaling by EGFR;Reactome;REACT:9417

Pathway

EPHB forward signaling;PID Curated;200041

Pathway

PDGF signaling pathway;PANTHER;P00047

Pathway

egf signaling pathway;PID BioCarta;100181

Pathway

aspirin blocks signaling pathway involved in platelet activation;PID BioCarta;100030

Pathway

EGF receptor signaling pathway;PANTHER;P00018

Pathway

regulation of splicing through sam68;PID BioCarta;100036

Pathway

inhibition of cellular proliferation by gleevec;PID BioCarta;100154

Pathway

Endothelins;PID Curated;200004

Pathway

Fc epsilon RI signaling pathway;KEGG PATHWAY;hsa04664

Pathway

how progesterone initiates the oocyte maturation;PID BioCarta;100104

Pathway

bcr signaling pathway;PID BioCarta;100227

Pathway

erk1/erk2 mapk signaling pathway;PID BioCarta;100170

Pathway

Bladder cancer;KEGG PATHWAY;hsa05219

Pathway

nfat and hypertrophy of the heart ;PID BioCarta;100098

Pathway

ccr3 signaling in eosinophils;PID BioCarta;100215

Pathway

tpo signaling pathway;PID BioCarta;100012

Pathway

mcalpain and friends in cell motility;PID BioCarta;100111

Pathway

Long-term depression;KEGG PATHWAY;hsa04730

Pathway

p53 pathway feedback loops 2;PANTHER;P04398

Pathway

trka receptor signaling pathway;PID BioCarta;100011

Pathway

role of egf receptor transactivation by gpcrs in cardiac hypertrophy;PID BioCarta;100221

Pathway

Syndecan-2-mediated signaling events;PID Curated;200164

Pathway

multiple antiapoptotic pathways from igf-1r signaling lead to bad phosphorylation;PID BioCarta;100135

Pathway

signaling pathway from g-protein families;PID BioCarta;100153

Pathway

Signaling events mediated by VEGFR1 and VEGFR2;PID Curated;200161

Pathway

BCR signaling pathway;PID Curated;200005

Pathway

Signaling by PDGF;Reactome;REACT:16888

Pathway

mapkinase signaling pathway;PID BioCarta;100113

Pathway

EGFR-dependent Endothelin signaling events;PID Curated;200095

Pathway

epo signaling pathway;PID BioCarta;100175

Pathway

mets affect on macrophage differentiation;PID BioCarta;100169

Pathway

B cell activation;PANTHER;P00010

Pathway

Prostate cancer;KEGG PATHWAY;hsa05215

Pathway

melanocyte development and pigmentation pathway;PID BioCarta;100108

Pathway

Angiogenesis;PANTHER;P00005

Pathway

phospholipids as signalling intermediaries;PID BioCarta;100183

Pathway

IGF1 pathway;PID Curated;200084

Pathway

Pathways in cancer;KEGG PATHWAY;hsa05200

Pathway

Thyroid cancer;KEGG PATHWAY;hsa05216

Pathway

Melanoma;KEGG PATHWAY;hsa05218

Pathway

Glioma;KEGG PATHWAY;hsa05214

Pathway

influence of ras and rho proteins on g1 to s transition;PID BioCarta;100054

Pathway

B cell receptor signaling pathway;KEGG PATHWAY;hsa04662

Pathway

Neurotrophin signaling pathway;KEGG PATHWAY;hsa04722

Pathway

Regulation of actin cytoskeleton;KEGG PATHWAY;hsa04810

Pathway

fmlp induced chemokine gene expression in hmc-1 cells;PID BioCarta;100162

Pathway

trefoil factors initiate mucosal healing;PID BioCarta;100018

Pathway

a6b1 and a6b4 Integrin signaling;PID Curated;200162

Pathway

Ras activation uopn Ca2+ infux through NMDA receptor;PID Reactome;500178

Pathway

T cell receptor signaling pathway;KEGG PATHWAY;hsa04660

Pathway

Axon guidance;KEGG PATHWAY;hsa04360

Pathway

Nongenotropic Androgen signaling;PID Curated;200145

Pathway

transcription factor creb and its extracellular signals;PID BioCarta;100198

Pathway

Inflammation mediated by chemokine and cytokine signaling pathway;PANTHER;P00031

Pathway

Signalling by NGF;Reactome;REACT:11061

Pathway

CDC42 signaling events;PID Curated;200057

Pathway

Insulin Pathway;PID Curated;200012

Pathway

bioactive peptide induced signaling pathway;PID BioCarta;100226

Pathway

Long-term potentiation;KEGG PATHWAY;hsa04720

Pathway

CREB phophorylation through the activation of Ras;PID Reactome;500177

Pathway

keratinocyte differentiation;PID BioCarta;100119

Pathway

Synaptic Transmission;Reactome;REACT:13685

Pathway

angiotensin ii mediated activation of jnk pathway via pyk2 dependent signaling;PID BioCarta;100236

Pathway

Integrin signalling pathway;PANTHER;P00034

Pathway

ras signaling pathway;PID BioCarta;100047

Pathway

Renal cell carcinoma;KEGG PATHWAY;hsa05211

Pathway

cxcr4 signaling pathway;PID BioCarta;100192

Pathway

nerve growth factor pathway (ngf);PID BioCarta;100096

Pathway

Hemostasis;Reactome;REACT:604

Pathway

role of mal in rho-mediated activation of srf;PID BioCarta;100114

Pathway

vegf hypoxia and angiogenesis;PID BioCarta;100006

Pathway

phosphorylation of mek1 by cdk5/p35 down regulates the map kinase pathway;PID BioCarta;100210

Pathway

Signaling events mediated by Stem cell factor receptor (c-Kit);PID Curated;200156

Pathway

Natural killer cell mediated cytotoxicity;KEGG PATHWAY;hsa04650

Pathway

Endocytosis;KEGG PATHWAY;hsa04144

Pathway

Signaling in Immune system;Reactome;REACT:6900

Pathway

Signaling events regulated by Ret tyrosine kinase;PID Curated;200058

Pathway

igf-1 signaling pathway;PID BioCarta;100136

Pathway

Fc-epsilon receptor I signaling in mast cells;PID Curated;200003

Pathway

Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met);PID Curated;200032

Pathway

LPA receptor mediated events;PID Curated;200011

Pathway

calcium signaling by hbx of hepatitis b virus;PID BioCarta;100150

Pathway

il 3 signaling pathway;PID BioCarta;100128

Pathway

Focal adhesion;KEGG PATHWAY;hsa04510

Pathway

Chronic myeloid leukemia;KEGG PATHWAY;hsa05220

Pathway

EPO signaling pathway;PID Curated;200157

Pathway

T cell activation;PANTHER;P00053

Pathway

role of erk5 in neuronal survival pathway;PID BioCarta;100171

Pathway

Hepatitis C;KEGG PATHWAY;hsa05160

Pathway

PI3 kinase pathway;PANTHER;P00048

Pathway

map kinase inactivation of smrt corepressor;PID BioCarta;100032

Pathway

roles of beta arrestin dependent recruitment of src kinases in gpcr signaling;PID BioCarta;100230

Pathway

Insulin signaling pathway;KEGG PATHWAY;hsa04910

Pathway

VEGF signaling pathway;KEGG PATHWAY;hsa04370

Pathway

VEGF signaling pathway;PANTHER;P00056

Pathway

ErbB signaling pathway;KEGG PATHWAY;hsa04012

Pathway

p38 mapk signaling pathway;PID BioCarta;100085

Pathway

links between pyk2 and map kinases;PID BioCarta;100057

Pathway

Non-small cell lung cancer;KEGG PATHWAY;hsa05223

Pathway

t cell receptor signaling pathway;PID BioCarta;100022

Pathway

il 2 signaling pathway;PID BioCarta;100130

Pathway

GnRH signaling pathway;KEGG PATHWAY;hsa04912

Pathway

fc epsilon receptor i signaling in mast cells;PID BioCarta;100165

Pathway

Gap junction;KEGG PATHWAY;hsa04540

Pathway

the igf-1 receptor and longevity;PID BioCarta;100115

Pathway

integrin signaling pathway;PID BioCarta;100123

Pathway

Chemokine signaling pathway;KEGG PATHWAY;hsa04062

Pathway

Tight junction;KEGG PATHWAY;hsa04530

Pathway

cadmium induces dna synthesis and proliferation in macrophages;PID BioCarta;100209

Pathway

il 6 signaling pathway;PID BioCarta;100126

Pathway

Ras Pathway;PANTHER;P04393

Pathway

Acute myeloid leukemia;KEGG PATHWAY;hsa05221

Disease

Thyroid cancer;KEGG DISEASE;H00032

Disease

bladder cancer;GAD

Disease

Cancer;FunDO

Disease

anomalous connection of pancreatobiliary ducts;GAD

Disease

Squamous cell carcinoma;KEGG DISEASE;H00040

Disease

H-ras allele loss;GAD

Disease

Eating disorder;FunDO

Disease

Skin cancers;KEGG DISEASE

Disease

Bladder cancer;KEGG DISEASE;H00022

Disease

Actinic keratosis;FunDO

Disease

Herpes;FunDO

Disease

Thyroid carcinoma, follicular, somatic;OMIM

Disease

lung cancer;GAD

Disease

cervical cancer;GAD

Disease

Systemic scleroderma;FunDO

Disease

tumor progression of BCR/ABL negative chronic myeloproliferative disorders;GAD

Disease

Cancers of endocrine organs;KEGG DISEASE

Disease

Cancers of the digestive system;KEGG DISEASE

Disease

nodular type of malignant melanoma;GAD

Disease

colorectal carcinomas;GAD

Disease

Drug abuse;FunDO

Disease

PSYCH;GAD

Disease

Penile disease;FunDO

Disease

schistosomiasis;GAD

Disease

Hepatocellular carcinoma;KEGG DISEASE;H00048

Disease

Penile cancer;KEGG DISEASE;H00025

Disease

CANCER;GAD

Disease

Pancreas disease;FunDO

Disease

Cancers of the breast and female genital organs;KEGG DISEASE

Disease

Costello syndrome;OMIM

Disease

Cancers;KEGG DISEASE

Disease

Bladder cancer, somatic;OMIM

Disease

thyroid cancer;GAD

Disease

Cervical cancer;KEGG DISEASE;H00030

Disease

Cancers of the urinary system and male genital organs;KEGG DISEASE

Disease

breast cancer;GAD

Disease

Autism;GAD

Disease

patient prognosis A retrospective study of 103 cases;GAD

Disease

adenocarcinomas of the parotid gland;GAD

External Links

Links to Entrez Gene

3265

Links to all GeneRIF Items

3265

Links to iHOP

3265

Sequence Information

Nucleotide Sequence

>3265 : length: 570
atgacggaatataagctggtggtggtgggcgccggcggtgtgggcaagagtgcgctgacc
atccagctgatccagaaccattttgtggacgaatacgaccccactatagaggattcctac
cggaagcaggtggtcattgatggggagacgtgcctgttggacatcctggataccgccggc
caggaggagtacagcgccatgcgggaccagtacatgcgcaccggggagggcttcctgtgt
gtgtttgccatcaacaacaccaagtcttttgaggacatccaccagtacagggagcagatc
aaacgggtgaaggactcggatgacgtgcccatggtgctggtggggaacaagtgtgacctg
gctgcacgcactgtggaatctcggcaggctcaggacctcgcccgaagctacggcatcccc
tacatcgagacctcggccaagacccggcagggagtggaggatgccttctacacgttggtg
cgtgagatccggcagcacaagctgcggaagctgaaccctcctgatgagagtggccccggc
tgcatgagctgcaagtgtgtgctctcctga

Protein Sequence

>3265 : length: 189
MTEYKLVVVGAGGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAG
QEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHQYREQIKRVKDSDDVPMVLVGNKCDL
AARTVESRQAQDLARSYGIPYIETSAKTRQGVEDAFYTLVREIRQHKLRKLNPPDESGPG
CMSCKCVLS



')