Epithelial-Mesenchymal Transition gene database (dbEMT) Home
dbEMT
Pediatric cancer database
General information | Literature | Expression | Regulation | Variant | Interaction

Basic Information

Gene ID

2064

Name

ERBB2

Synonym

CD340|HER-2|HER-2/neu|HER2|MLN 19|NEU|NGL|TKR1;v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian);ERBB2;v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)

Definition

c-erb B2/neu protein|herstatin|metastatic lymph node gene 19 protein|neuroblastoma/glioblastoma derived oncogene homolog|p185erbB2|proto-oncogene Neu|proto-oncogene c-ErbB-2|receptor tyrosine-protein kinase erbB-2|tyrosine kinase-type cell surface recepto

Position

17q11.2-q12|17q21.1

Gene Type

protein-coding

Pathways and Diseases

Pathway

Pancreatic cancer;KEGG PATHWAY;hsa05212

Pathway

Adherens junction;KEGG PATHWAY;hsa04520

Pathway

ErbB2/ErbB3 signaling events;PID Curated;200119

Pathway

Sema4D induced cell migration and growth-cone collapse;PID Reactome;500074

Pathway

a6b1 and a6b4 Integrin signaling;PID Curated;200162

Pathway

Calcium signaling pathway;KEGG PATHWAY;hsa04020

Pathway

Focal adhesion;KEGG PATHWAY;hsa04510

Pathway

role of erbb2 in signal transduction and oncology;PID BioCarta;100147

Pathway

Axon guidance;Reactome;REACT:18266

Pathway

ErbB signaling pathway;KEGG PATHWAY;hsa04012

Pathway

Cadherin signaling pathway;PANTHER;P00012

Pathway

Endometrial cancer;KEGG PATHWAY;hsa05213

Pathway

Prostate cancer;KEGG PATHWAY;hsa05215

Pathway

EGF receptor signaling pathway;PANTHER;P00018

Pathway

Non-small cell lung cancer;KEGG PATHWAY;hsa05223

Pathway

ErbB4 signaling events;PID Curated;200009

Pathway

ErbB receptor signaling network;PID Curated;200136

Pathway

Validated targets of C-MYC transcriptional repression;PID Curated;200171

Pathway

Pathways in cancer;KEGG PATHWAY;hsa05200

Pathway

trefoil factors initiate mucosal healing;PID BioCarta;100018

Pathway

Bladder cancer;KEGG PATHWAY;hsa05219

Disease

Cholangiocarcinoma;KEGG DISEASE;H00046

Disease

Gastric cancer, somatic;OMIM

Disease

Ovarian cancer, somatic;OMIM

Disease

Gastric cancer;KEGG DISEASE;H00018

Disease

Pancreatic cancer;KEGG DISEASE;H00019

Disease

Osteitis deformans;FunDO

Disease

overall effect;GAD

Disease

Cleft Lip;GAD

Disease

Tooth Abnormalities;GAD

Disease

Cancer;FunDO

Disease

Oral cancer;FunDO

Disease

DEVELOPMENTAL;GAD

Disease

Bladder cancer;KEGG DISEASE;H00022

Disease

Rheumatoid arthritis;FunDO

Disease

Pulmonary fibrosis;FunDO

Disease

prostate cancer;GAD

Disease

Choriocarcinoma;KEGG DISEASE;H00028

Disease

Cancers of the digestive system;KEGG DISEASE

Disease

Pneumoconiosis;FunDO

Disease

Adenocarcinoma of lung, somatic;OMIM

Disease

breast cancer colorectal cancer stomach cancer;GAD

Disease

Drug abuse;FunDO

Disease

Breast cancer;KEGG DISEASE;H00031

Disease

Charcot-Marie-Tooth disease;FunDO

Disease

Cleft Palate;GAD

Disease

gastric cancer;GAD

Disease

Ovarian cancer;KEGG DISEASE;H00027

Disease

Testicular dysfunction;FunDO

Disease

Endometrial cancer;KEGG DISEASE;H00026

Disease

Yersinia infection;FunDO

Disease

Cancers of the breast and female genital organs;KEGG DISEASE

Disease

breast cancer recurrence;GAD

Disease

Cancers;KEGG DISEASE

Disease

Papillomavirus infection;FunDO

Disease

Cervical cancer;KEGG DISEASE;H00030

Disease

Cancers of the urinary system and male genital organs;KEGG DISEASE

Disease

breast cancer;GAD

Disease

CANCER;GAD

Disease

Glioblastoma, somatic;OMIM

Disease

stomach cancer;GAD

External Links

Links to Entrez Gene

2064

Links to all GeneRIF Items

2064

Links to iHOP

2064

Sequence Information

Nucleotide Sequence

>2064 : length: 3678
atgaagctgcggctccctgccagtcccgagacccacctggacatgctccgccacctctac
cagggctgccaggtggtgcagggaaacctggaactcacctacctgcccaccaatgccagc
ctgtccttcctgcaggatatccaggaggtgcagggctacgtgctcatcgctcacaaccaa
gtgaggcaggtcccactgcagaggctgcggattgtgcgaggcacccagctctttgaggac
aactatgccctggccgtgctagacaatggagacccgctgaacaataccacccctgtcaca
ggggcctccccaggaggcctgcgggagctgcagcttcgaagcctcacagagatcttgaaa
ggaggggtcttgatccagcggaacccccagctctgctaccaggacacgattttgtggaag
gacatcttccacaagaacaaccagctggctctcacactgatagacaccaaccgctctcgg
gcctgccacccctgttctccgatgtgtaagggctcccgctgctggggagagagttctgag
gattgtcagagcctgacgcgcactgtctgtgccggtggctgtgcccgctgcaaggggcca
ctgcccactgactgctgccatgagcagtgtgctgccggctgcacgggccccaagcactct
gactgcctggcctgcctccacttcaaccacagtggcatctgtgagctgcactgcccagcc
ctggtcacctacaacacagacacgtttgagtccatgcccaatcccgagggccggtataca
ttcggcgccagctgtgtgactgcctgtccctacaactacctttctacggacgtgggatcc
tgcaccctcgtctgccccctgcacaaccaagaggtgacagcagaggatggaacacagcgg
tgtgagaagtgcagcaagccctgtgcccgagtgtgctatggtctgggcatggagcacttg
cgagaggtgagggcagttaccagtgccaatatccaggagtttgctggctgcaagaagatc
tttgggagcctggcatttctgccggagagctttgatggggacccagcctccaacactgcc
ccgctccagccagagcagctccaagtgtttgagactctggaagagatcacaggttaccta
tacatctcagcatggccggacagcctgcctgacctcagcgtcttccagaacctgcaagta
atccggggacgaattctgcacaatggcgcctactcgctgaccctgcaagggctgggcatc
agctggctggggctgcgctcactgagggaactgggcagtggactggccctcatccaccat
aacacccacctctgcttcgtgcacacggtgccctgggaccagctctttcggaacccgcac
caagctctgctccacactgccaaccggccagaggacgagtgtgtgggcgagggcctggcc
tgccaccagctgtgcgcccgagggcactgctggggtccagggcccacccagtgtgtcaac
tgcagccagttccttcggggccaggagtgcgtggaggaatgccgagtactgcaggggctc
cccagggagtatgtgaatgccaggcactgtttgccgtgccaccctgagtgtcagccccag
aatggctcagtgacctgttttggaccggaggctgaccagtgtgtggcctgtgcccactat
aaggaccctcccttctgcgtggcccgctgccccagcggtgtgaaacctgacctctcctac
atgcccatctggaagtttccagatgaggagggcgcatgccagccttgccccatcaactgc
acccactcctgtgtggacctggatgacaagggctgccccgccgagcagagagccagccct
ctgacgtccatcatctctgcggtggttggcattctgctggtcgtggtcttgggggtggtc
tttgggatcctcatcaagcgacggcagcagaagatccggaagtacacgatgcggagactg
ctgcaggaaacggagctggtggagccgctgacacctagcggagcgatgcccaaccaggcg
cagatgcggatcctgaaagagacggagctgaggaaggtgaaggtgcttggatctggcgct
tttggcacagtctacaagggcatctggatccctgatggggagaatgtgaaaattccagtg
gccatcaaagtgttgagggaaaacacatcccccaaagccaacaaagaaatcttagacgaa
gcatacgtgatggctggtgtgggctccccatatgtctcccgccttctgggcatctgcctg
acatccacggtgcagctggtgacacagcttatgccctatggctgcctcttagaccatgtc
cgggaaaaccgcggacgcctgggctcccaggacctgctgaactggtgtatgcagattgcc
aaggggatgagctacctggaggatgtgcggctcgtacacagggacttggccgctcggaac
gtgctggtcaagagtcccaaccatgtcaaaattacagacttcgggctggctcggctgctg
gacattgacgagacagagtaccatgcagatgggggcaaggtgcccatcaagtggatggcg
ctggagtccattctccgccggcggttcacccaccagagtgatgtgtggagttatggtgtg
actgtgtgggagctgatgacttttggggccaaaccttacgatgggatcccagcccgggag
atccctgacctgctggaaaagggggagcggctgccccagccccccatctgcaccattgat
gtctacatgatcatggtcaaatgttggatgattgactctgaatgtcggccaagattccgg
gagttggtgtctgaattctcccgcatggccagggacccccagcgctttgtggtcatccag
aatgaggacttgggcccagccagtcccttggacagcaccttctaccgctcactgctggag
gacgatgacatgggggacctggtggatgctgaggagtatctggtaccccagcagggcttc
ttctgtccagaccctgccccgggcgctgggggcatggtccaccacaggcaccgcagctca
tctaccaggagtggcggtggggacctgacactagggctggagccctctgaagaggaggcc
cccaggtctccactggcaccctccgaaggggctggctccgatgtatttgatggtgacctg
ggaatgggggcagccaaggggctgcaaagcctccccacacatgaccccagccctctacag
cggtacagtgaggaccccacagtacccctgccctctgagactgatggctacgttgccccc
ctgacctgcagcccccagcctgaatatgtgaaccagccagatgttcggccccagccccct
tcgccccgagagggccctctgcctgctgcccgacctgctggtgccactctggaaaggccc
aagactctctccccagggaagaatggggtcgtcaaagacgtttttgcctttgggggtgcc
gtggagaaccccgagtacttgacaccccagggaggagctgcccctcagccccaccctcct
cctgccttcagcccagccttcgacaacctctattactgggaccaggacccaccagagcgg
ggggctccacccagcaccttcaaagggacacctacggcagagaacccagagtacctgggt
ctggacgtgccagtgtga

Protein Sequence

>2064 : length: 1225
MKLRLPASPETHLDMLRHLYQGCQVVQGNLELTYLPTNASLSFLQDIQEVQGYVLIAHNQ
VRQVPLQRLRIVRGTQLFEDNYALAVLDNGDPLNNTTPVTGASPGGLRELQLRSLTEILK
GGVLIQRNPQLCYQDTILWKDIFHKNNQLALTLIDTNRSRACHPCSPMCKGSRCWGESSE
DCQSLTRTVCAGGCARCKGPLPTDCCHEQCAAGCTGPKHSDCLACLHFNHSGICELHCPA
LVTYNTDTFESMPNPEGRYTFGASCVTACPYNYLSTDVGSCTLVCPLHNQEVTAEDGTQR
CEKCSKPCARVCYGLGMEHLREVRAVTSANIQEFAGCKKIFGSLAFLPESFDGDPASNTA
PLQPEQLQVFETLEEITGYLYISAWPDSLPDLSVFQNLQVIRGRILHNGAYSLTLQGLGI
SWLGLRSLRELGSGLALIHHNTHLCFVHTVPWDQLFRNPHQALLHTANRPEDECVGEGLA
CHQLCARGHCWGPGPTQCVNCSQFLRGQECVEECRVLQGLPREYVNARHCLPCHPECQPQ
NGSVTCFGPEADQCVACAHYKDPPFCVARCPSGVKPDLSYMPIWKFPDEEGACQPCPINC
THSCVDLDDKGCPAEQRASPLTSIISAVVGILLVVVLGVVFGILIKRRQQKIRKYTMRRL
LQETELVEPLTPSGAMPNQAQMRILKETELRKVKVLGSGAFGTVYKGIWIPDGENVKIPV
AIKVLRENTSPKANKEILDEAYVMAGVGSPYVSRLLGICLTSTVQLVTQLMPYGCLLDHV
RENRGRLGSQDLLNWCMQIAKGMSYLEDVRLVHRDLAARNVLVKSPNHVKITDFGLARLL
DIDETEYHADGGKVPIKWMALESILRRRFTHQSDVWSYGVTVWELMTFGAKPYDGIPARE
IPDLLEKGERLPQPPICTIDVYMIMVKCWMIDSECRPRFRELVSEFSRMARDPQRFVVIQ
NEDLGPASPLDSTFYRSLLEDDDMGDLVDAEEYLVPQQGFFCPDPAPGAGGMVHHRHRSS
STRSGGGDLTLGLEPSEEEAPRSPLAPSEGAGSDVFDGDLGMGAAKGLQSLPTHDPSPLQ
RYSEDPTVPLPSETDGYVAPLTCSPQPEYVNQPDVRPQPPSPREGPLPAARPAGATLERP
KTLSPGKNGVVKDVFAFGGAVENPEYLTPQGGAAPQPHPPPAFSPAFDNLYYWDQDPPER
GAPPSTFKGTPTAENPEYLGLDVPV



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