Epithelial-Mesenchymal Transition gene database (dbEMT) Home
dbEMT
Pediatric cancer database
General information | Literature | Expression | Regulation | Variant | Interaction

Basic Information

Gene ID

1956

Name

EGFR

Synonym

ERBB|ERBB1|HER1|PIG61|mENA;epidermal growth factor receptor;EGFR;epidermal growth factor receptor

Definition

avian erythroblastic leukemia viral (v-erb-b) oncogene homolog|cell growth inhibiting protein 40|cell proliferation-inducing protein 61|proto-oncogene c-ErbB-1|receptor tyrosine-protein kinase erbB-1

Position

7p12

Gene Type

protein-coding

Pathways and Diseases

Pathway

agrin in postsynaptic differentiation;PID BioCarta;100252

Pathway

Endocytosis;KEGG PATHWAY;hsa04144

Pathway

Signaling events mediated by TCPTP;PID Curated;200065

Pathway

angiotensin ii mediated activation of jnk pathway via pyk2 dependent signaling;PID BioCarta;100236

Pathway

Calcium signaling pathway;KEGG PATHWAY;hsa04020

Pathway

Axon guidance;Reactome;REACT:18266

Pathway

Regulation of actin cytoskeleton;KEGG PATHWAY;hsa04810

Pathway

MAPK signaling pathway;KEGG PATHWAY;hsa04010

Pathway

Endometrial cancer;KEGG PATHWAY;hsa05213

Pathway

E-cadherin signaling in keratinocytes;PID Curated;200125

Pathway

Syndecan-3-mediated signaling events;PID Curated;200170

Pathway

sprouty regulation of tyrosine kinase signals;PID BioCarta;100029

Pathway

trefoil factors initiate mucosal healing;PID BioCarta;100018

Pathway

Pancreatic cancer;KEGG PATHWAY;hsa05212

Pathway

Adherens junction;KEGG PATHWAY;hsa04520

Pathway

EGFR downregulation;PID Reactome;500515

Pathway

a6b1 and a6b4 Integrin signaling;PID Curated;200162

Pathway

Signaling by EGFR;Reactome;REACT:9417

Pathway

Regulation of Telomerase;PID Curated;200072

Pathway

Focal adhesion;KEGG PATHWAY;hsa04510

Pathway

GnRH signaling pathway;KEGG PATHWAY;hsa04912

Pathway

EGFR-dependent Endothelin signaling events;PID Curated;200095

Pathway

egf signaling pathway;PID BioCarta;100181

Pathway

cbl mediated ligand-induced downregulation of egf receptors pathway;PID BioCarta;100216

Pathway

EGF receptor (ErbB1) signaling pathway;PID Curated;200085

Pathway

EGF receptor signaling pathway;PANTHER;P00018

Pathway

Hepatitis C;KEGG PATHWAY;hsa05160

Pathway

Cytokine-cytokine receptor interaction;KEGG PATHWAY;hsa04060

Pathway

Dorso-ventral axis formation;KEGG PATHWAY;hsa04320

Pathway

Signaling by EGFR;PID Reactome;500510

Pathway

map kinase inactivation of smrt corepressor;PID BioCarta;100032

Pathway

LPA receptor mediated events;PID Curated;200011

Pathway

Signaling events mediated by PTP1B;PID Curated;200033

Pathway

ErbB signaling pathway;KEGG PATHWAY;hsa04012

Pathway

Cadherin signaling pathway;PANTHER;P00012

Pathway

keratinocyte differentiation;PID BioCarta;100119

Pathway

Direct p53 effectors;PID Curated;200101

Pathway

Epithelial cell signaling in Helicobacter pylori infection;KEGG PATHWAY;hsa05120

Pathway

Thromboxane A2 receptor signaling;PID Curated;200069

Pathway

Prostate cancer;KEGG PATHWAY;hsa05215

Pathway

ErbB1 downstream signaling;PID Curated;200113

Pathway

Non-small cell lung cancer;KEGG PATHWAY;hsa05223

Pathway

Signal transduction by L1;PID Reactome;500100

Pathway

ErbB receptor signaling network;PID Curated;200136

Pathway

Pathways in cancer;KEGG PATHWAY;hsa05200

Pathway

Bladder cancer;KEGG PATHWAY;hsa05219

Pathway

Melanoma;KEGG PATHWAY;hsa05218

Pathway

Glioma;KEGG PATHWAY;hsa05214

Pathway

Gap junction;KEGG PATHWAY;hsa04540

Pathway

Arf6 signaling events;PID Curated;200060

Pathway

mcalpain and friends in cell motility;PID BioCarta;100111

Pathway

Internalization of ErbB1;PID Curated;200146

Pathway

Stabilization and expansion of the E-cadherin adherens junction;PID Curated;200155

Pathway

role of egf receptor transactivation by gpcrs in cardiac hypertrophy;PID BioCarta;100221

Disease

CANCER;GAD

Disease

Lupus erythematosus;FunDO

Disease

IMMUNE;GAD

Disease

Gastric cancer;KEGG DISEASE;H00018

Disease

Gastrointestinal tumor;FunDO

Disease

Cholelithiasis;FunDO

Disease

Cytomegalovirus infection;FunDO

Disease

Nonsmall cell lung cancer, response to tyrosine kinase inhibitor in;OMIM

Disease

Atopic rhinitis;FunDO

Disease

Asthma;FunDO

Disease

Cancer;FunDO

Disease

Oral cancer;FunDO

Disease

glioblastoma multiforme;GAD

Disease

Acute Coronary Syndrome;GAD

Disease

Bladder cancer;KEGG DISEASE;H00022

Disease

Esotropia;FunDO

Disease

Hypercholesterolemia;FunDO

Disease

Barrett's esophagus;FunDO

Disease

Pleural effusion, Malignant;FunDO

Disease

lung cancer;GAD

Disease

prostatic hyperplasia;GAD

Disease

anaplastic astrocytoma;GAD

Disease

pancreatic cancer;GAD

Disease

brain cancer;GAD

Disease

prostate cancer;GAD

Disease

PHARMACOGENOMIC;GAD

Disease

Choriocarcinoma;KEGG DISEASE;H00028

Disease

Asthma;GAD

Disease

Exanthema;GAD

Disease

Cancers of the digestive system;KEGG DISEASE

Disease

Cardiomyopathy, Dilated;GAD

Disease

Stroke;FunDO

Disease

Yersinia infection;FunDO

Disease

Glaucoma;FunDO

Disease

colorectal cancer;GAD

Disease

Drug abuse;FunDO

Disease

Adenocarcinoma of lung, response to tyrosine kinase inhibitor in;OMIM

Disease

radiation sensitivity;GAD

Disease

Diabetes mellitus;FunDO

Disease

Thrombophlebitis;FunDO

Disease

rectal cancer;GAD

Disease

lupus erythematosus;GAD

Disease

Lung Neoplasms;GAD

Disease

CARDIOVASCULAR;GAD

Disease

Adenovirus infection;FunDO

Disease

Schizophrenia;FunDO

Disease

Testicular dysfunction;FunDO

Disease

Oral cancer;KEGG DISEASE;H00016

Disease

Laryngeal cancer;KEGG DISEASE;H00055

Disease

Cancers of the breast and female genital organs;KEGG DISEASE

Disease

Endometriosis;FunDO

Disease

Carcinoma, Non-Small-Cell Lung;GAD

Disease

Cancers of the nervous system;KEGG DISEASE

Disease

Cancers;KEGG DISEASE

Disease

Cervical cancer;KEGG DISEASE;H00030

Disease

Optic atrophy;FunDO

Disease

Cancers of the urinary system and male genital organs;KEGG DISEASE

Disease

head and neck cancer;GAD

Disease

Primary hyperparathyroidism;FunDO

Disease

Skin cancer;FunDO

Disease

Glioma;KEGG DISEASE;H00042

Disease

Papillary adenocarcinoma;FunDO

Disease

polycystic kidney disease;GAD

Disease

Head and neck cancers;KEGG DISEASE

Disease

Nonsmall cell lung cancer, susceptibility to;OMIM

Disease

RENAL;GAD

Disease

Esophageal cancer;KEGG DISEASE;H00017

Disease

Common wart;FunDO

Disease

Angiomyolipoma;FunDO

External Links

Links to Entrez Gene

1956

Links to all GeneRIF Items

1956

Links to iHOP

1956

Sequence Information

Nucleotide Sequence

>1956 : length: 3633
atgcgaccctccgggacggccggggcagcgctcctggcgctgctggctgcgctctgcccg
gcgagtcgggctctggaggaaaagaaagtttgccaaggcacgagtaacaagctcacgcag
ttgggcacttttgaagatcattttctcagcctccagaggatgttcaataactgtgaggtg
gtccttgggaatttggaaattacctatgtgcagaggaattatgatctttccttcttaaag
accatccaggaggtggctggttatgtcctcattgccctcaacacagtggagcgaattcct
ttggaaaacctgcagatcatcagaggaaatatgtactacgaaaattcctatgccttagca
gtcttatctaactatgatgcaaataaaaccggactgaaggagctgcccatgagaaattta
caggaaatcctgcatggcgccgtgcggttcagcaacaaccctgccctgtgcaacgtggag
agcatccagtggcgggacatagtcagcagtgactttctcagcaacatgtcgatggacttc
cagaaccacctgggcagctgccaaaagtgtgatccaagctgtcccaatgggagctgctgg
ggtgcaggagaggagaactgccagaaactgaccaaaatcatctgtgcccagcagtgctcc
gggcgctgccgtggcaagtcccccagtgactgctgccacaaccagtgtgctgcaggctgc
acaggcccccgggagagcgactgcctggtctgccgcaaattccgagacgaagccacgtgc
aaggacacctgccccccactcatgctctacaaccccaccacgtaccagatggatgtgaac
cccgagggcaaatacagctttggtgccacctgcgtgaagaagtgtccccgtaattatgtg
gtgacagatcacggctcgtgcgtccgagcctgtggggccgacagctatgagatggaggaa
gacggcgtccgcaagtgtaagaagtgcgaagggccttgccgcaaagtgtgtaacggaata
ggtattggtgaatttaaagactcactctccataaatgctacgaatattaaacacttcaaa
aactgcacctccatcagtggcgatctccacatcctgccggtggcatttaggggtgactcc
ttcacacatactcctcctctggatccacaggaactggatattctgaaaaccgtaaaggaa
atcacagggtttttgctgattcaggcttggcctgaaaacaggacggacctccatgccttt
gagaacctagaaatcatacgcggcaggaccaagcaacatggtcagttttctcttgcagtc
gtcagcctgaacataacatccttgggattacgctccctcaaggagataagtgatggagat
gtgataatttcaggaaacaaaaatttgtgctatgcaaatacaataaactggaaaaaactg
tttgggacctccggtcagaaaaccaaaattataagcaacagaggtgaaaacagctgcaag
gccacaggccaggtctgccatgccttgtgctcccccgagggctgctggggcccggagccc
agggactgcgtctcttgccggaatgtcagccgaggcagggaatgcgtggacaagtgcaac
cttctggagggtgagccaagggagtttgtggagaactctgagtgcatacagtgccaccca
gagtgcctgcctcaggccatgaacatcacctgcacaggacggggaccagacaactgtatc
cagtgtgcccactacattgacggcccccactgcgtcaagacctgcccggcaggagtcatg
ggagaaaacaacaccctggtctggaagtacgcagacgccggccatgtgtgccacctgtgc
catccaaactgcacctacggatgcactgggccaggtcttgaaggctgtccaacgaatggg
cctaagatcccgtccatcgccactgggatggtgggggccctcctcttgctgctggtggtg
gccctggggatcggcctcttcatgcgaaggcgccacatcgttcggaagcgcacgctgcgg
aggctgctgcaggagagggagcttgtggagcctcttacacccagtggagaagctcccaac
caagctctcttgaggatcttgaaggaaactgaattcaaaaagatcaaagtgctgggctcc
ggtgcgttcggcacggtgtataagggactctggatcccagaaggtgagaaagttaaaatt
cccgtcgctatcaaggaattaagagaagcaacatctccgaaagccaacaaggaaatcctc
gatgaagcctacgtgatggccagcgtggacaacccccacgtgtgccgcctgctgggcatc
tgcctcacctccaccgtgcagctcatcacgcagctcatgcccttcggctgcctcctggac
tatgtccgggaacacaaagacaatattggctcccagtacctgctcaactggtgtgtgcag
atcgcaaagggcatgaactacttggaggaccgtcgcttggtgcaccgcgacctggcagcc
aggaacgtactggtgaaaacaccgcagcatgtcaagatcacagattttgggctggccaaa
ctgctgggtgcggaagagaaagaataccatgcagaaggaggcaaagtgcctatcaagtgg
atggcattggaatcaattttacacagaatctatacccaccagagtgatgtctggagctac
ggggtgaccgtttgggagttgatgacctttggatccaagccatatgacggaatccctgcc
agcgagatctcctccatcctggagaaaggagaacgcctccctcagccacccatatgtacc
atcgatgtctacatgatcatggtcaagtgctggatgatagacgcagatagtcgcccaaag
ttccgtgagttgatcatcgaattctccaaaatggcccgagacccccagcgctaccttgtc
attcagggggatgaaagaatgcatttgccaagtcctacagactccaacttctaccgtgcc
ctgatggatgaagaagacatggacgacgtggtggatgccgacgagtacctcatcccacag
cagggcttcttcagcagcccctccacgtcacggactcccctcctgagctctctgagtgca
accagcaacaattccaccgtggcttgcattgatagaaatgggctgcaaagctgtcccatc
aaggaagacagcttcttgcagcgatacagctcagaccccacaggcgccttgactgaggac
agcatagacgacaccttcctcccagtgcctgaatacataaaccagtccgttcccaaaagg
cccgctggctctgtgcagaatcctgtctatcacaatcagcctctgaaccccgcgcccagc
agagacccacactaccaggacccccacagcactgcagtgggcaaccccgagtatctcaac
actgtccagcccacctgtgtcaacagcacattcgacagccctgcccactgggcccagaaa
ggcagccaccaaattagcctggacaaccctgactaccagcaggacttctttcccaaggaa
gccaagccaaatggcatctttaagggctccacagctgaaaatgcagaatacctaagggtc
gcgccacaaagcagtgaatttattggagcatga

Protein Sequence

>1956 : length: 1210
MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEV
VLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALA
VLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDF
QNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGC
TGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYV
VTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFK
NCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAF
ENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKL
FGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCN
LLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVM
GENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVV
ALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGS
GAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGI
CLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAA
RNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSY
GVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPK
FRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQ
QGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTED
SIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLN
TVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRV
APQSSEFIGA



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